Hemoglobin Constant Spring is markedly high in women of an ethnic minority group in Vietnam: a community-based survey and hematologic features
| Autor: | Van Thang Vo, Van Hoa Nguyen, Supan Fucharoen, Kasama Wongprachum, Mau Duyen Nguyen, Kanokwan Sanchaisuriya, Frank Peter Schelp, Pattara Sanchaisuriya, Thi Thuy Hoa Phan |
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| Rok vydání: | 2013 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities Pediatrics medicine.medical_specialty Heterozygote Minority group Thalassemia Hemoglobins Abnormal Ethnic group Community based survey Asian People Gene Frequency hemic and lymphatic diseases Internal medicine Epidemiology medicine Prevalence Humans Molecular Biology Allele frequency Alleles Minority Groups Hemoglobin Constant Spring Geography business.industry Homozygote Cell Biology Hematology medicine.disease Hemoglobinopathies Vietnam Molecular Medicine Female Hemoglobin business |
| Zdroj: | Blood cells, moleculesdiseases. 52(4) |
| ISSN: | 1096-0961 |
| Popis: | A community-based survey was conducted to determine the prevalence and gene frequency of Hemoglobin Constant Spring (Hb CS) and other forms of thalassemia among an ethnic minority in Vietnam. A total of 298 ethnic minority women, the Co-Tu, participated. Hematological parameters and hemoglobin profiles were analyzed using standard automated analyzers. Alpha- and beta-thalassemia mutations were identified using polymerase chain reaction (PCR) based technology. Of the 298 women, 141 (47.3%) carried thalassemia genes. Hemoglobin Constant Spring (Hb CS) is the most common with a markedly high frequency of 0.143 (overall prevalence = 26.2%). The heterozygous state of Hb CS was found in one-fifth (20.5%) of women participating. Seven women (2.4%) were Hb CS homozygote. The overall prevalence for Hb E was 13.8%, and 10.7% for α + -thalassemia. Other forms of thalassemia included 0.67% β-thalassemia, and 0.34% Hb Pakse. None of the participants had the α 0 -thalassemia gene. The study provides basic epidemiological information about Hb CS as well as other forms of thalassemia for a specific group of an ethnic minority in Vietnam. The data will be useful for further study on the distribution of thalassemia in Southeast Asia. |
| Databáze: | OpenAIRE |
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