The mammalian toxicity of methacrylonitrile
| Autor: | King Jm, Kinkead Er, U.C. Pozzani |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
Adult
Male Chromatography Gas Cyanide Guinea Pigs Thiosulfates Male mice Pharmacology Toxicology chemistry.chemical_compound Mice Dogs Nitriles Animals Humans Nitrites Cyanides Inhalation Body Weight Public Health Environmental and Occupational Health Environmental Exposure Organ Size Middle Aged Cyanide ion Rats Occupational Diseases chemistry Methacrylonitrile Toxicity Female Mammalian toxicity Rabbits Standard therapy Plastics |
| Zdroj: | American Industrial Hygiene Association journal. 29(3) |
| ISSN: | 0002-8894 |
| Popis: | Single-dose rabbit dermal and rat intragastric studies indicate that methacrylonitrile is highly toxic by both routes. The LG50 values for single four-hour inhalation periods varied from 700 ppm of the vapor for female rats to 36 ppm for male mice. Methacrylonitrile formed cyanide ion in the blood of rats and rabbits and its effects were diminished by the standard therapy for cyanide intoxication. Human sensory response studies showed that the vapor has very poor warning properties. The response of rats and dogs to repeated 7-hour exposures of methacrylonitrile vapor for 91 and 90 days respectively, suggest that humans should not be allowed to inhale more than three ppm vapor for eight hours per day, five days per week. It should be emphasized that this “Hygienic Standard,” is an estimate based on experimental data and therefore is subject to modification as data are gathered on human experience. |
| Databáze: | OpenAIRE |
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