A pilot study of essential tremor: cerebellar GABA+/Glx ratio is correlated with tremor severity
| Autor: | Nathanael Göransson, Peter Zsigmond, Sofie Tapper, Anders Tisell, Peter Lundberg |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Cerebellum Essential tremor GABA Glutamate MEGA-PRESS Magnetic resonance spectroscopy Neurology Neurologi Thalamus Inhibitory postsynaptic potential lcsh:RC346-429 030218 nuclear medicine & medical imaging 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Neurotransmitter lcsh:Neurology. Diseases of the nervous system business.industry Research Glutamate receptor medicine.disease nervous system diseases Endocrinology medicine.anatomical_structure chemistry nervous system Excitatory postsynaptic potential Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Cerebellum & Ataxias, Vol 7, Iss 1, Pp 1-11 (2020) Cerebellum & Ataxias |
| Popis: | Objective Essential tremor is a common movement disorder with an unclear origin. Emerging evidence suggests the role of the cerebellum and the thalamus in tremor pathophysiology. We examined the two main neurotransmitters acting inhibitory (GABA+) and excitatory (Glx) respectively, in the thalamus and cerebellum, in patients diagnosed with severe essential tremor. Furthermore, we also investigated the relationship between determined neurotransmitter concentrations and tremor severity in the essential tremor patients. Methods Ten essential tremor patients (prior to deep brain stimulation surgery) and six healthy controls, were scanned using a 3 T MR system. GABA+ and Glx concentrations were measured using magnetic resonance spectroscopy (MRS) performed using single voxel MEGA-PRESS. For the purpose of assessing the tremor severity, the essential tremor rating scale (ETRS) was used in accordance with Fahn, Tolosa, and Marin. Results We demonstrated that the cerebellar GABA+/Glx ratio was positively correlated to the ETRS (r = 0.70, p = 0.03) in essential tremor. Cerebellar and thalamic GABA+ and Glx concentrations did not show any significant difference when comparing essential tremor patients with healthy controls, at the group level. Conclusion We demonstrated a positive correlation between increasing tremor disability and the ratio of GABA+/ Glx in the cerebellum of essential tremor patients. This highlights the impact of an altered balance of the excitatory and inhibitory neurotransmitters in tremor severity. Rather than a change in GABA+, which was constant, we attribute this finding to an overall decrease of Glx. |
| Databáze: | OpenAIRE |
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