Early treatment improves growth and biochemical and radiographic outcome in X-linked hypophosphatemic rickets
| Autor: | Andrea S. Doria, Outi Mäkitie, William G. Cole, Alan Daneman, Etienne Sochett, Sang Whay Kooh |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Hypophosphatemia Endocrinology Diabetes and Metabolism Radiography Clinical Biochemistry Rickets Bone healing Growth Biochemistry Bone and Bones Endocrinology Calcitriol Internal medicine Medicine Humans Age of Onset Child Hypophosphatemia Familial Retrospective Studies business.industry Biochemistry (medical) Infant Retrospective cohort study medicine.disease X-linked hypophosphatemia Body Height Hypophosphatemic Rickets Treatment Outcome Child Preschool Age of onset business |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 88(8) |
| ISSN: | 0021-972X |
| Popis: | X-Linked hypophosphatemic rickets (XLH) is characterized by hypophosphatemia, rickets, and impaired growth. Despite oral phosphate and 1,25-dihydroxyvitamin D3 treatment, many patients have suboptimal growth and bone healing. The aim of this study was to assess whether age at treatment onset impacts the outcome. Growth data, biochemistry, and radiographs of 19 well-controlled patients with XLH were analyzed retrospectively. Patients were divided into two groups based on the age at treatment onset (group 1, 0.05) and until predicted adult height (−0.2 SDS vs. −1.2 SDS; P = 0.06). The degree of hypophosphatemia was similar in both groups, but serum alkaline phosphatase remained higher in group 2 throughout childhood. Radiographic signs of rickets were more marked in group 2, but even patients with early treatment developed significant skeletal changes of rickets. These data suggest that treatment commenced in early infancy results in improved outcome in patients with XLH, but does not completely normalize skeletal development. |
| Databáze: | OpenAIRE |
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