Sickle cell disease associated with uric acid deposition disease
| Autor: | C W Sienknecht, J S Spindler, S B Kaplan, B M Rothschild |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Adult
Male musculoskeletal diseases congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Pathology Gout Immunology Cell Arthritis Anemia Sickle Cell Disease Gastroenterology General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Impaired renal function Rheumatology Internal medicine medicine Humans Immunology and Allergy Foot business.industry nutritional and metabolic diseases Middle Aged Hand medicine.disease Pathophysiology Radiography medicine.anatomical_structure chemistry Uric acid Synovial membrane business Research Article |
| Zdroj: | Annals of the Rheumatic Diseases. 39:392-395 |
| ISSN: | 0003-4967 |
| DOI: | 10.1136/ard.39.4.392 |
| Popis: | The infrequent occurrence of gout in patients with sickle cell anaemia contrast with the high incidence of hyperuricaemia and impaired renal function. This report records the third case of synovial membrane uric acid deposition and the first case of tophaceous deposits in haemoglobin SS patients. The limitations of a diagnosis of gout on the basis of hyperuricaemia and arthritis are confirmed. Analysis of reported cases suggests the existence of 2 forms of arthritis associated with sickle cell anaemia--noninflammatory and inflammatory. Paradoxically, gout appears to be associated with the former, in which the pathophysiological changes probably prevent or diminish the acute inflammatory response. |
| Databáze: | OpenAIRE |
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