High Complement Factor I Activity in the Plasma of Children with Autism Spectrum Disorders
| Autor: | Berit Nordström, Bengt Sivberg, Mohammad T. Joghataei, Ali Yosefi-Oudarji, Fatemeh Behnia, Naghi Momeni, Bengt Persson, Lars Brudin |
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| Rok vydání: | 2012 |
| Předmět: |
Psychiatry
medicine.medical_specialty Pediatrics Neurology Article Subject lcsh:RC435-571 business.industry ComputingMilieux_LEGALASPECTSOFCOMPUTING General Medicine Complement factor I medicine.disease Complement system Immune system lcsh:Psychiatry mental disorders Immunology Clinical Study medicine Autism Abnormality business Opsonin Biomedical sciences |
| Zdroj: | Autism Research and Treatment, Vol 2012 (2012) Autism Research and Treatment Autism Research and Treatment; 2012, no 868576 (2012) |
| ISSN: | 2090-1933 2090-1925 |
| Popis: | Autism spectrum disorders (ASDs) are neurodevelopmental and behavioural syndromes affecting social orientation, behaviour, and communication that can be classified as developmental disorders. ASD is also associated with immune system abnormality. Immune system abnormalities may be caused partly by complement system factor I deficiency. Complement factor I is a serine protease present in human plasma that is involved in the degradation of complement protein C3b, which is a major opsonin of the complement system. Deficiency in factor I activity is associated with an increased incidence of infections in humans. In this paper, we show that the mean level of factor I activity in the ASD group is significantly higher than in the control group of typically developed and healthy children, suggesting that high activity of complement factor I might have an impact on the development of ASD. |
| Databáze: | OpenAIRE |
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