Models of wound healing: an emphasis on clinical studies
| Autor: | D. Wilhelm, K.-P. Wilhelm, Stephan Bielfeldt |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Biopsy Abrasion (medical) Wounds Penetrating Dermatology Lacerations Clinical study 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine Humans Surgical Tape Intensive care medicine Skin Wound Healing integumentary system business.industry medicine.disease Suction blister 030104 developmental biology Treatment modality Dermabrasion Full thickness Wound healing business |
| Zdroj: | Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). 23(1) |
| ISSN: | 1600-0846 |
| Popis: | Background The healing of wounds has always provided challenges for the medical community whether chronic or acute. Understanding the processes which enable wounds to heal is primarily carried out by the use of models, in vitro, animal and human. It is generally accepted that the use of human models offers the best opportunity to understand the factors that influence wound healing as well as to evaluate efficacy of treatments applied to wounds. Objectives The objective of this article is to provide an overview of the different methodologies that are currently used to experimentally induce wounds of various depths in human volunteers and examines the information that may be gained from them. Methods There is a number of human volunteer healing models available varying in their invasiveness to reflect the different possible depth levels of wounds. Results Currently available wound healing models include sequential tape stripping, suction blister, abrasion, laser, dermatome, and biopsy techniques. The various techniques can be utilized to induce wounds of variable depth, from removing solely the stratum corneum barrier, the epidermis to even split-thickness or full thickness wounds. Conclusion Depending on the study objective, a number of models exist to study wound healing in humans. These models provide efficient and reliable results to evaluate treatment modalities. |
| Databáze: | OpenAIRE |
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