Changes in Circulating Endothelial Cells Count Could Become a Valuable Tool in the Diagnostic Definition of Acute Graft-Versus-Host Disease
| Autor: | Alessandro Turra, Michele Malagola, Simona Braga, Mirella Marini, Andrea Bianchetti, Camillo Almici, Arabella Neva, Domenico Russo, Andrea Di Palma, Cristina Skert, Rosanna Verardi |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Risk medicine.medical_specialty Transplantation Conditioning Adolescent Acute myeloblastic leukemia Chronic lymphocytic leukemia medicine.medical_treatment Graft vs Host Disease Cell Count Cell Separation Hematopoietic stem cell transplantation Gastroenterology immune system diseases Internal medicine Humans Transplantation Homologous Medicine Prospective Studies Multiple myeloma Transplantation business.industry Hematopoietic Stem Cell Transplantation Endothelial Cells Myeloid leukemia Odds ratio Middle Aged medicine.disease Confidence interval Lymphoma surgical procedures operative Hematologic Neoplasms Immunology Female Endothelium Vascular business |
| Popis: | BACKGROUND Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is burdened by life-threatening complications, with graft-versus-host disease (GvHD) being the major cause of morbility and mortality. Recently, clinical and physiopathologic evidences showed that vascular endothelium can be a target of GvHD in the early phase and circulating endothelial cells (CECs) represent surrogate markers of endothelial damage. METHODS Using the CellSearch System (Veridex LLC, Raritan, NJ), CECs were counted before (T1), after conditioning regimen (T2), at engraftment (T3), at GvHD onset (T4), and after steroid treatment (T5) in 40 patients (7 Hodgkin's Disease, 13 Acute Myeloblastic Leukemia, 5 Acute Lymphoblastic Leukemia, 8 Multiple Myeloma, 3 Chronic Lymphocytic Leukemia, 1 Non-Hodgkin Lymphoma, 1 Chronic Myeloid Leukemia, 2 Severe Aplastic Anemia) undergoing allo-HSCT. RESULTS The median CEC per milliliter at T1 was 20 (n=33, range 4-718), in comparison to a value of 2 (range, 1-14) in controls (P |
| Databáze: | OpenAIRE |
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