No evidence for the involvement of serotonin or the 5-HTTLPR genotype in intertemporal choice in a larger community sample
| Autor: | Yacila I Deza-Araujo, Marcella Rietschel, Philipp T. Neukam, Michael Marxen, Shakoor Pooseh, Uwe Schwarzenbolz, Michael N. Smolka |
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| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
medicine.diagnostic_test Serotonin 5-HTTLPR intertemporal choice functional magnetic resonance imaging tryptophan intervention Serotonin 5-HTTLPR intertemporale Wahl funktionelle Magnetresonanztomographie Tryptophan-Intervention Intertemporal choice Tonic (physiology) Psychiatry and Mental health 5-HTTLPR Genotype medicine Pharmacology (medical) ddc:610 Serotonin Animal studies Temporal discounting Psychology Functional magnetic resonance imaging Neuroscience |
| Zdroj: | Journal of Psychopharmacology. 33:1377-1387 |
| ISSN: | 1461-7285 0269-8811 |
| DOI: | 10.1177/0269881119874417 |
| Popis: | Background: Serotonin has been implicated in impulsive behaviours such as temporal discounting. While animal studies and theoretical approaches suggest that reduced tonic serotonin levels increase temporal discounting rates and vice versa, evidence from human studies is scarce and inconclusive. Furthermore, an important modulator of serotonin signalling, a genetic variation in the promoter region of the serotonin transporter gene ( 5-HTTLPR), has not been investigated for temporal discounting so far. Objective: First, the purpose of this study was to test for a significant association between 5-HTTLPR and temporal discounting. Second, we wished to investigate the effect of high/low tonic serotonin levels on intertemporal choice and blood oxygen-level-dependent response, controlling for 5-HTTLPR. Methods: We tested the association of 5-HTTLPR with temporal discounting rates using an intertemporal choice task in 611 individuals. We then manipulated tonic serotonin levels with acute tryptophan interventions (depletion, loading, balanced) in a subsample of 45 short (S)-allele and 45 long (L)/L-allele carriers in a randomised double-blind crossover design using functional magnetic resonance imaging and an intertemporal choice task. Results: Overall, we did not find any effect of serotonin and 5-HTTLPR on temporal discounting rates or the brain networks associated with valuation and cognitive control. Conclusion: Our findings indicate that serotonin may not be directly involved in choices including delays on longer timescales such as days, weeks or months. We speculate that serotonin plays a stronger role in dynamic intertemporal choice tasks where the delays are on a timescale of seconds and hence are therefore directly experienced during the experiment. |
| Databáze: | OpenAIRE |
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