Imaging of calcium and aluminum in neurofibrillary tangle-bearing neurons in parkinsonism-dementia of Guam
| Autor: | C E Fiori, D. C. Gajdusek, Richard Yanagihara, Ryo Fukatsu, G Hook, Ralph M. Garruto |
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| Rok vydání: | 1984 |
| Předmět: |
Pathology
medicine.medical_specialty Central nervous system Hippocampus chemistry.chemical_element Calcium medicine Humans Amyotrophic lateral sclerosis Cytoskeleton Aged Multidisciplinary Magnesium Parkinson Disease Neurofibrillary tangle Anatomy Middle Aged medicine.disease medicine.anatomical_structure chemistry Guam Secondary hyperparathyroidism Pyramidal cell Research Article Aluminum |
| Zdroj: | Proceedings of the National Academy of Sciences. 81:1875-1879 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.81.6.1875 |
| Popis: | We report the distribution and imaging of calcium and aluminum in neurofibrillary tangle (NFT)-bearing neurons within Sommer's sector of the hippocampus in Guamanian patients with parkinsonism-dementia, using a method of computer-controlled electron beam x-ray micro-analysis and wavelength dispersive spectrometry. Calcium and aluminum were distributed in cell bodies and axonal processes of NFT-bearing neurons. The elemental images show that both calcium and aluminum deposits occur within the same NFT-bearing hippocampal neuron in this dementing disease, suggesting that these elements are involved in NFT formation. No prominent concentrations of calcium and aluminum were imaged in non-NFT-containing regions within the pyramidal cell layer of the parkinsonism-dementia cases or in the control cases. These findings support the hypothesis that secondary hyperparathyroidism resulting from low environmental calcium and magnesium in the high-incidence focus of amyotrophic lateral sclerosis and parkinsonism-dementia on Guam had led to abnormal deposition of calcium and aluminum in the central nervous system. |
| Databáze: | OpenAIRE |
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