Octyl p-methoxycinnamate loaded microemulsion based on Ocimum basilicum essential oil. Characterization and analytical studies for potential cosmetic applications
| Autor: | Matías Insausti, Marcos Grunhut, Danielle Silva Do Nascimento, Verónica Volpe |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
food.ingredient
Dispersity UV filter 02 engineering and technology 010402 general chemistry 01 natural sciences MICROEMULSION law.invention chemistry.chemical_compound Colloid and Surface Chemistry food Linalool law Microemulsion Essential oil biology Ciencias Químicas Basilicum OCTYL P-METHOXYCINNAMATE 021001 nanoscience & nanotechnology Ocimum biology.organism_classification 0104 chemical sciences MOSQUITO REPELLENT ESSENTIAL OIL ANTIINFLAMMATORY ACTIVITY chemistry OCIMUM BASILICUM Química Analítica Estragole 0210 nano-technology CIENCIAS NATURALES Y EXACTAS PHOTOLYSIS STUDY Nuclear chemistry |
| Zdroj: | Colloids and Surfaces A: Physicochemical and Engineering Aspects. 546:285-292 |
| ISSN: | 0927-7757 |
| Popis: | A O/W microemulsion based on biocompatible materials was designed for a potential topical use as UVB filter, antiinflamatory and mosquito repellent. Octyl-p-methoxy cinnamate (OMC) is one of the most widely used sunscreen compounds. Nevertheless, their efficiency as UV filter is affected by irradiation because a photolysis process occurs. Ocimum basilicum essential oil is utilized in traditional medicine and as repellent of insects, among others. Hence, the proposed O/W microemulsion consisted of 6.0% of Ocimum basilicum essential oil (oil phase), 23% of a 2:1 mixture of decaethylene glycol mono-dodecyl ether (surfactant) and ethanol (co-surfactant), and 71% of water. OMC was successfully loaded in the O/W microemulsion (1.5%). The loaded system presented a particle size of (12.60 ± 0.10) nm and a polydispersity index of 0.389 ± 0.042. A spherical morphology and droplet sizes in nanometric range were corroborated by transmission electronic microscopy. The higher photostability of OMC in the O/W microemulsion with respect to the free-OMC was demonstrated by calculating the photolysis kinetic constants (0.00186 s−1 and 0.00457 s−1, respectively) which were obtained through a photolysis study assisted by multivariate curve resolution-alternating least squares algorithm. Moreover, the stability of the system over time and under different conditions was demonstrated. On the other hand, a chromatographic analysis of the essential oil corroborated the presence of estragole (93.2%) which presents a documented antiinflammatory activity, and seven compounds with a well reported mosquito repellent activity, such as linalool (2.81%), cineole (0.57%), among others. On this form, the proposed O/W microemulsion presents optimal chemical and physicochemical characteristics for a potential application in cosmetic product. Fil: Volpe, Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina Fil: Silva Do Nascimento, Danielle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina Fil: Insausti, Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina Fil: Grunhut, Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina |
| Databáze: | OpenAIRE |
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