Resolving Digital Staphylococcal Osteomyelitis Using Bacteriophage—A Case Report
| Autor: | Gordon Wheat, Randolph Fish, Sarah J. Kuhl, Daniel Bryan, Elizabeth Kutter |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty Staphylococcus aureus phage therapy Phage therapy medicine.medical_treatment 030106 microbiology Case Report Biochemistry Microbiology 03 medical and health sciences Antibiotic resistance medicine Pharmacology (medical) Bacteriophages General Pharmacology Toxicology and Pharmaceutics business.industry Osteomyelitis Standard treatment lcsh:RM1-950 osteomyelitis medicine.disease Diabetic foot Surgery 030104 developmental biology Infectious Diseases Diabetic foot ulcer lcsh:Therapeutics. Pharmacology Amputation business diabetic foot ulcer Foot (unit) |
| Zdroj: | Antibiotics, Vol 7, Iss 4, p 87 (2018) Antibiotics |
| ISSN: | 2079-6382 |
| Popis: | Infections involving diabetic foot ulcers (DFU) are a major public health problem and have a substantial negative impact on patient outcomes. Osteomyelitis in an ulcerated foot substantially increases the difficulty of successful treatment. While literature suggests that osteomyelitis in selected patients can sometimes be treated conservatively, with no, or minimal removal of bone, we do not yet have clear treatment guidelines and the standard treatment failure fallback remains amputation. The authors report on the successful treatment, with a long term follow up, of a 63 YO diabetic female with distal phalangeal osteomyelitis using bacteriophage, a form of treatment offering the potential for improved outcomes in this era of escalating antibiotic resistance and the increasingly recognized harms associated with antibiotic therapy. |
| Databáze: | OpenAIRE |
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