Antibody response against saliva antigens of Anopheles gambiae and Aedes aegypti in travellers in tropical Africa
| Autor: | Catherine Bourgouin, Didier Fontenille, Franck Remoue, Aurélie Pascual, Laure Denis de Senneville, Denis Boulanger, Eve Orlandi-Pradines, Paul Reiter, Christophe Rogier, Sylvie Cornelie, Solenne Barbe, Claude Villard, Bruno Pradines, Kristell Penhoat, Thierry Fusai, Frédéric Pagès, Julien Bonnet, Lionel Almeras, Nicole Corre-Catelin, François Simondon, Daniel Laffite |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Saliva Anopheles gambiae Molecular Sequence Data Immunology malaria Aedes aegypti Microbiology Arbovirus Antigen stomatognathic system vectors Aedes Anopheles parasitic diseases medicine Animals Humans Amino Acid Sequence Gabon Vector (molecular biology) Antigens Salivary Proteins and Peptides proteomic Travel saliva biology antibody response biology.organism_classification medicine.disease Virology Insect Vectors Cote d'Ivoire Military Personnel Infectious Diseases arbovirus Immunoglobulin M Immunoglobulin G travellers France |
| Popis: | Exposure to vectors of infectious diseases has been associated with antibody responses against salivary antigens of arthropods among people living in endemic areas. This immune response has been proposed as a surrogate marker of exposure to vectors appropriate for evaluating the protective efficacy of antivectorial devices. The existence and potential use of such antibody responses in travellers transiently exposed to Plasmodium or arbovirus vectors in tropical areas has never been investigated. The IgM and IgG antibody responses of 88 French soldiers against the saliva of Anopheles gambiae and Aedes aegypti were evaluated before and after a 5-month journey in tropical Africa. Antibody responses against Anopheles and Aedes saliva increased significantly in 41% and 15% of the individuals, respectively, and appeared to be specific to the mosquito genus. A proteomic and immunoproteomic analysis of anopheles and Aedes saliva allowed for the identification of some antigens that were recognized by most of the exposed individuals. These results suggest that antibody responses to the saliva of mosquitoes could be considered as specific surrogate markers of exposure of travellers to mosquito vectors that transmit arthropod borne infections. |
| Databáze: | OpenAIRE |
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