Testing of Perilla frutescens extract and Vicenin 2 for their antispasmodic effect
| Autor: | Hajime Fujii, Eugen J. Verspohl, Kohei Homma, Sybille Buchwald-Werner |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
Contraction (grammar) Stereochemistry Barium Compounds Drug Evaluation Preclinical Pharmaceutical Science Ileum Stimulation Pharmacology Chlorides Glucosides Drug Discovery medicine Animals Apigenin Perilla frutescens biology Chemistry Plant Extracts Parasympatholytics biology.organism_classification Acetylcholine Rats Plant Leaves medicine.anatomical_structure Complementary and alternative medicine Molecular Medicine Gastrointestinal discomfort Antispasmodic Effect Female medicine.drug Muscle Contraction |
| Zdroj: | Phytomedicine : international journal of phytotherapy and phytopharmacology. 20(5) |
| ISSN: | 1618-095X |
| Popis: | Gastrointestinal discomfort is frequently observed. The effects of Perilla frutescens extract and Vicenin 2 (a compound in this extract) were assayed in rat ileum with or without stimulation with acetylcholine or Ba(2+). Both had no direct spasmolytic effect, but both decreased acetylcholine- or Ba(2+)-induced contraction of rat ileum indicating an antispasmodic effect. This is valuable because effects were only observed when spasms were induced and may disturb the patient. The extract and the compound may be used to maintain and improve gut health. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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