Sarcomas of the sellar region: a systematic review
| Autor: | Nuria Vilarrasa, Carles Villabona, Juan José Sánchez-Fernández, Macarena López-Vázquez, Noemi Vidal, Alberto Torres-Diaz, Fernando Guerrero-Pérez, Reinaldo Sánchez-Barrera |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Soft Tissue Neoplasms 030209 endocrinology & metabolism Bone Sarcoma 03 medical and health sciences 0302 clinical medicine Endocrinology medicine Animals Humans Fibrosarcoma Rhabdomyosarcoma business.industry Mortality rate Soft tissue Sarcoma Middle Aged medicine.disease Primary tumor Radiation therapy Radiology Neoplasm Recurrence Local business 030217 neurology & neurosurgery |
| Zdroj: | Pituitary. 24:117-129 |
| ISSN: | 1573-7403 1386-341X |
| Popis: | Sarcomas of the sellar region are uncommon and unexpected tumors. Here, we review the cases reported in literature via a systematic search. Ninety-four patients, 58.5% male with mean age of 39.2 ± 17.2 years were included. Fifty-seven (62%) had soft tissue sarcomas (STS) and 35 (38%) bone sarcomas (BS). Sarcoma was a primary tumor in 66%, developed after radiotherapy in 31.9% and 7.4% were metastatic. Median time between radiotherapy and sarcoma development was 10.5 (11) years. Main presentation symptoms were visual disorders (87.9%), headache (61.5%) and III cranial nerve palsy (24.1%). After surgery, sarcoma persisted or recurred in 82.3% and overall mortality reported was 44.6% with 6.5 (14) months of median survival. Tumor appeared earlier in BS compared to STS (34.4 ± 15.1 vs. 42.6 ± 17.6 years), p = 0.034 and complete tumor resection was achieved more often (41.3% vs. 4.4%), p = |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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