Estrogen Deficiency Influences Hematological Parameters Following Bone Fracture in OVX Rats
| Autor: | Shanil Juma, Joseph Munoz, Bahram H. Arjmandi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Nutrition and Dietetics Aging and Chronic Disease medicine.drug_class business.industry Osteoporosis Medicine (miscellaneous) Inflammation Bone fracture Bone healing medicine.disease Rats sprague dawley Endocrinology Estrogen Internal medicine medicine Fibula medicine.symptom business hormones hormone substitutes and hormone antagonists Food Science |
| Zdroj: | Curr Dev Nutr |
| Popis: | OBJECTIVES: Estrogen deficiency in postmenopausal women contributes to the development of osteoporosis. Furthermore, estrogen deficiency is associated with significant changes in hematological parameters including inflammatory markers. Since inflammation contributes to the pathophysiology of osteoporosis, the relationship between bone fracture, estrogen deficiency, and hematological parameters warrant investigation. Using an ovariectomized (OVX) rat model of postmenopausal osteoporosis, the objective of this research was to investigate the extent to which bone fracture in conditions of low estrogen affects hematological parameters compared to bone fracture in estrogen sufficient conditions. METHODS: 12-month old Sprague Dawley rats were randomized into one of four groups (1. OVX + Fracture, 2. OVX + no fracture, 3. Sham + fracture, 4. Sham + no fracture). Rats randomized into the OVX + fracture and sham + fracture groups underwent fracture of the right fibula. After sacrificing the animals, blood was collected for analysis of hematological parameters. RESULTS: All data are presented as mean ± S.E. As expected, OVX induced significant changes in hematological parameters compared to Sham. OVX compared to sham increased WBC (5.78 ± 0.93 vs. 1.73 ± 0.93 P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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