Etomidate by infusion for neuroanaesthesia
| Autor: | D. G. Wilkins, Sheila M. Willatts, F. J. M. Walters, John W. Sear |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Metabolic Clearance Rate Group ii Nitrous Oxide chemistry.chemical_compound Etomidate Humans Medicine Drug Interactions Infusions Parenteral Date of birth Aged Plasma clearance Oxygen deficient business.industry Mean value Imidazoles Nitrous oxide Middle Aged Spine Spinal surgery Surgery Kinetics Anesthesiology and Pain Medicine chemistry Anesthesia Anesthesia Intravenous Female business medicine.drug |
| Zdroj: | Anaesthesia. 39:12-18 |
| ISSN: | 1365-2044 0003-2409 |
| Popis: | Summary An etomidate infusion was used to anaesthetise twelve patients for spinal surgery; six (group I) with 67% nitrous oxide and six (group II) with oxygen enriched air. Anaesthesia was induced with infused etomidate at a rate of 100 μg/kg/minute for 10 minutes and maintained at a rate of 10 μg/kg/minute. Recovery was assessed as the time to opening eyes on command (t1) and the time to giving correct date of birth (t2). In group I, mean value for t1 was 37.9 minutes and t2 59.1 minutes which is significantly longer than in group II where mean value for t1 was 9.0 minutes and t2 15.1 minutes. Blood was taken for estimation of etomidate levels. In group I the maintenance level was 501 ng/ml and the plasma clearance 20.9 ml/kg/minute. In group II the maintenance level was 367 ng/ml and plasma clearance 27.3 ml/kg/minute. Etomidate infusion appears to be a suitable alternative for neuroanaesthesia when nitrous oxide is contra-indicated. |
| Databáze: | OpenAIRE |
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