LUNG DISTRIBUTION OF THE CHEMOPREVENTIVE AGENT DIFLUOROMETHYLORNITHINE (DFMO) FOLLOWING ORAL AND INHALATION DELIVERY

Autor:	Xiangmin Liao, Timothy S. Wiedmann, Wei Liang, Lee W. Wattenberg, Alan R. Dahl
Rok vydání:	2004
Předmět:	Pulmonary and Respiratory Medicine Eflornithine Mice Inbred A Clinical Biochemistry Administration Oral Antineoplastic Agents Pharmacology Mice Pharmacokinetics Oral administration Administration Inhalation medicine Animals Distribution (pharmacology) Lung cancer Lung Molecular Biology Inhalation business.industry Respiratory disease Area under the curve medicine.disease medicine.anatomical_structure Area Under Curve Anesthesia Female business
Zdroj:	Experimental Lung Research. 30:755-769
ISSN:	1521-0499 0190-2148
Popis:	The inhalation delivery of difluoromethylornithine (DFMO) was evaluated to determine its feasibility for use in lung cancer chemoprevention. Aerosol droplets of DFMO were produced, and the solvent was removed by a reflux drying column. Equivalent doses of DFMO (40 mg/kg) were given over 10 minutes by inhalation and by gavage, and the serum and tissue levels were determined. Inhalation of DFMO resulted in a peak lung concentration 80 times higher and area under the curve (AUC) that was 35 times higher than oral dosing. The estimated pharmacokinetic advantage based on serum and lung AUCs was 13 in favor of inhalation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b266c14857699e69948db62b93679f https://doi.org/10.1080/01902140490517836 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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