T1R3: A human calcium taste receptor
| Autor: | Laura K. Alarcón, Sitaram Valmeki, Michael G. Tordoff, Peihua Jiang |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Taste Gene Expression chemistry.chemical_element Calcium Article Receptors G-Protein-Coupled Calcium Chloride 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Taste receptor Internal medicine Benzene Derivatives medicine Humans Receptor 030304 developmental biology Lactisole Calcium metabolism 0303 health sciences Multidisciplinary Dose-Response Relationship Drug fungi HEK 293 cells Taste Perception food and beverages Calcium Compounds HEK293 Cells Endocrinology chemistry Lactates 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep00496 |
| Popis: | Many animals can detect the taste of calcium but it is unclear how or whether humans have this ability. We show here that calcium activates hTAS1R3-transfected HEK293 cells and that this response is attenuated by lactisole, an inhibitor of hT1R3. Moreover, trained volunteers report that lactisole reduces the calcium intensity of calcium lactate. Thus, humans can detect calcium by taste, T1R3 is a receptor responsible for this, and lactisole can reduce the taste perception of calcium by acting on T1R3. |
| Databáze: | OpenAIRE |
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