Blunted blood pressure response to exercise and isolated muscle metaboreflex activation in patients with cirrhosis
| Autor: | Fábio Heleno de Lima Pace, Mateus Camaroti Laterza, Janaína Becari Moreira, Pedro Augusto de Carvalho Mira, Tarsila Campanha da Rocha Ribeiro, Kátia Valéria Bastos Dias Barbosa, Daniel Godoy Martinez, Rosa Virginia Diaz Guerrero, Maria Fernanda Almeida Falci |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Cirrhosis Physiology Endocrinology Diabetes and Metabolism Blood Pressure 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Physiology (medical) Internal medicine Humans Medicine In patient Muscle Skeletal Exercise Nutrition and Dietetics Hand Strength business.industry 030229 sport sciences General Medicine Middle Aged medicine.disease body regions Forearm Blood pressure Regional Blood Flow Case-Control Studies Cardiology Female business Muscle Contraction |
| Zdroj: | Applied Physiology, Nutrition, and Metabolism. 46:273-279 |
| ISSN: | 1715-5320 1715-5312 |
| DOI: | 10.1139/apnm-2020-0407 |
| Popis: | We sought to test the hypothesis that the cardiovascular responses to isolated muscle metaboreflex activation would be blunted in patients with cirrhosis. Eleven patients with cirrhosis and 15 healthy controls were evaluated. Blood pressure (BP; oscillometric method), contralateral forearm blood flow (FBF; venous occlusion plethysmography), and heart rate (HR; electrocardiogram) were measured during baseline, isometric handgrip at 30% of maximal voluntary contraction followed by postexercise ischemia (PEI). Forearm vascular conductance (FVC) was calculated as follows: (FBF / mean BP) × 100. Changes in HR during handgrip were similar between groups but tended to be different during PEI (controls: Δ 0.5 ± 1.1 bpm vs. cirrhotic patients: Δ 3.6 ± 1.0 bpm, P = 0.057). Mean BP response to handgrip (controls: Δ 20.9 ± 2.7 mm Hg vs. cirrhotic patients: Δ 10.6 ± 1.5 mm Hg, P = 0.006) and PEI was attenuated in cirrhotic patients (controls: Δ 16.1 ± 1.9 mm Hg vs. cirrhotic patients: Δ 7.2 ± 1.4 mm Hg, P = 0.001). In contrast, FBF and FVC increased during handgrip and decreased during PEI similarly between groups. These results indicate that an abnormal muscle metaboreflex activation explained, at least partially, the blunted pressor response to exercise exhibited by cirrhotic patients. Novelty: Patients with cirrhosis present abnormal muscle metaboreflex activation. BP response was blunted but forearm vascular response was preserved. HR response was slightly elevated. |
| Databáze: | OpenAIRE |
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