Heightened Exercise-Induced Oxidative Stress at Simulated Moderate Level Altitude vs. Sea Level in Trained Cyclists
| Autor: | Alexander J. Wadley, Michael Gleeson, Ida S. Svendsen |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Thiobarbituric acid Medicine (miscellaneous) Altitude Sickness medicine.disease_cause Severity of Illness Index Protein Carbonylation chemistry.chemical_compound 0302 clinical medicine Orthopedics and Sports Medicine Hypoxia Rating of perceived exertion Cross-Over Studies Nutrition and Dietetics biology General Medicine Catalase medicine.symptom Adult Atmosphere Exposure Chambers medicine.medical_specialty Physical Exertion Athletic Performance Young Adult 03 medical and health sciences Oxygen Consumption Altitude Internal medicine Heart rate medicine TBARS Humans Exercise business.industry Hypoxia (medical) Bicycling Surgery Oxidative Stress 030104 developmental biology Endocrinology chemistry Athletes biology.protein Lipid Peroxidation business Biomarkers 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | International Journal of Sport Nutrition and Exercise Metabolism. 27:97-104 |
| ISSN: | 1543-2742 1526-484X |
| DOI: | 10.1123/ijsnem.2015-0345 |
| Popis: | Altitude exposure can exaggerate the transient increase in markers of oxidative stress observed following acute exercise. However, these responses have not been monitored in endurance-trained cyclists at altitudes typically experienced while training. Endurance trained males (n = 12; mean (± SD) age: 28 ± 4 years, V̇O2max 63.7 ± 5.3 ml/kg/min) undertook two 75-min exercise trials at 70% relative V̇O2max; once in normoxia and once in hypobaric hypoxia, equivalent to 2000m above sea level (hypoxia). Blood samples were collected before, immediately after and 2 h postexercise to assess plasma parameters of oxidative stress (protein carbonylation (PC), thiobarbituric acid reactive substances (TBARS), total antioxidant capacity (TAC) and catalase activity (CAT)). Participants cycled at 10.5% lower power output in hypoxia vs. normoxia, with no differences in heart rate, blood lactate or rating of perceived exertion observed. PC increased and decreased immediately after exercise in hypoxia and normoxia respectively (nmol/mg/protein: Normoxia—0.3 ± 0.1, Hypoxia + 0.4 ± 0.1; both p < .05). CAT increased immediately postexercise in both trials, with the magnitude of change greater in hypoxia (nmol/min/ml: Normoxia + 12.0 ± 5.0, Hypoxia + 27.7 ± 4.8; both p < .05). CAT was elevated above baseline values at 2 h postexercise in Hypoxia only (Normoxia + 0.2 ± 2.4, Hypoxia + 18.4 ± 5.2; p < .05). No differences were observed in the changes in TBARS and TAC between hypoxia and normoxia. Trained male cyclists demonstrated a differential pattern/ timecourse of changes in markers of oxidative stress following submaximal exercise under hypoxic vs. normoxic conditions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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