Extended fish short term reproduction assays with the fathead minnow and Japanese medaka: No evidence of impaired fecundity from exposure to atrazine
| Autor: | Loren D. Knopper, Mark L. Hanson, Julie C. Anderson, Jeffrey C. Wolf, Richard A. Brain, Suzanne Z. Schneider |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Environmental Engineering Health Toxicology and Mutagenesis Oryzias 010501 environmental sciences 01 natural sciences 03 medical and health sciences Vitellogenin chemistry.chemical_compound Sex Factors Animal science biology.animal Animals Environmental Chemistry Atrazine Gonads 0105 earth and related environmental sciences biology Herbicides Reproduction Ovary Public Health Environmental and Occupational Health General Medicine General Chemistry Japanese Medaka Minnow biology.organism_classification Fecundity Pollution Gonadosomatic Index Fertility 030104 developmental biology chemistry biology.protein Female Pimephales promelas Water Pollutants Chemical |
| Zdroj: | Chemosphere. 205:126-136 |
| ISSN: | 0045-6535 |
| Popis: | Short-term reproduction assays were conducted with fathead minnow (Pimephales promelas) and Japanese medaka (Oryzias latipes) to evaluate responses from atrazine exposure at environmentally relevant concentrations and above. Breeding groups of fish with multiple males and females were exposed to atrazine under flow-through conditions. Fathead minnows were exposed to mean measured concentrations of 1.0, 10, 26, 52, and 105 μg atrazine/L for 28 days. Medaka were exposed to mean measured concentrations of 9.4, 48, 74, 97, and 244 μg atrazine/L for 28 or 29 days. Fish were evaluated for survival, fecundity, fertility, total length, wet weight, secondary sex characteristics, gonadosomatic index (GSI) (P. promelas only), plasma or hepatic vitellogenin (VTG), and histopathology of gonads. General observations of health and behaviour were also conducted. There were no statistically significant effects (i.e., p 0.05) of atrazine on survival, size, reproduction, behaviour, GSI, VTG, or secondary sex characteristics in either species at any exposure level. In fathead minnows, there were no histopathological findings associated with atrazine exposure in male fish, but there was an increased proportion of Stage 4.0 ovaries accompanied by an increase in proportion of Grade 3 post-ovulatory follicles in females of the 105 μg/L treatment group. Without a concomitant increase in oocyte atresia, neither of these findings are considered adverse for the health of the fish. In medaka, there were no significant effects of atrazine exposure on histopathology in either sex. These data support current weight-of-evidence assessments that atrazine does not cause direct adverse effects on fish reproduction at environmentally realistic concentrations. |
| Databáze: | OpenAIRE |
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