Biotin studies in pigs
| Autor: | J. S. Kopinski, Jane Leibholz, R.J. Love |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
Vitamin medicine.medical_specialty Swine Biotin Medicine (miscellaneous) Ileum Urine Kidney Excretion Caecum Feces chemistry.chemical_compound Oral administration Internal medicine medicine Animals Carbon Radioisotopes Cecum Nutrition and Dietetics biology Myocardium digestive oral and skin physiology biology.organism_classification Diet medicine.anatomical_structure Endocrinology Intestinal Absorption Liver chemistry Digestion |
| Zdroj: | British Journal of Nutrition. 62:781-789 |
| ISSN: | 1475-2662 0007-1145 |
| Popis: | Six pigs were given a biotin-deficient diet (10 μg biotin/kg) for 14 weeks. The pigs were given the same diet for a further 42 d with one of three biotin treatments: no supplement, 400 μg biotin/d given orally, 400 μg biotin/d infused into the caecum. The concentrations of biotin in the liver, kidney and heart, at the conclusion of 42 d were greater in the pigs given the oral biotin supplement than in the unsupplemented pigs. The values for the pigs given the caecal infusion of biotin were intermediate. The excretion of biotin in faeces was increased from 35 to 101 μg/d by the caecal biotin infusion, and the urinary excretion was increased from 35 to 83 μg/d. The oral dose of biotin increased urinary biotin excretion from 35 to 345 μg/d, but there was no change in faecal biotin excretion. Two pigs were fitted with ileal cannulas and catheters in the vena cava. The pigs were given a dose of [14C] biotin either into the caecum, when the ileum was occluded by a bladder catheter, or orally. [14C] biotin was measured in the urine and plasma and showed that post-ileal biotin absorption was 8 % as efficient as the absorption of biotin after oral dosing. |
| Databáze: | OpenAIRE |
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