Association of the adiponectin gene rs1501299 GT variant, serum adiponectin levels, and the risk of coronary artery disease in a Chinese population
| Autor: | Ming-Hui Gui, Daru Lu, Jian Gao, Xiang Li, Sun-Fang Jiang, Xin Gao |
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| Rok vydání: | 2012 |
| Předmět: |
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medicine.medical_specialty Endocrinology Diabetes and Metabolism Population Single-nucleotide polymorphism Coronary Artery Disease ADIPOQ Gene Polymorphism Single Nucleotide Endocrinology Asian People Gene Frequency Polymorphism (computer science) Risk Factors Internal medicine Genotype Internal Medicine medicine Humans Genetic Predisposition to Disease cardiovascular diseases education Allele frequency Genetic Association Studies Aged education.field_of_study Adiponectin business.industry Case-control study General Medicine Middle Aged Genetics Population Case-Control Studies Female business |
| Zdroj: | Diabetes research and clinical practice. 97(3) |
| ISSN: | 1872-8227 |
| Popis: | Background The present study aimed to investigate whether the single nucleotide polymorphism (SNP) 276G>T (rs1501299) of the adiponectin (ADIPOQ) gene was associated with the risk of coronary artery disease (CAD) and serum adiponectin levels in a Chinese population. Methods The rs1501299 polymorphism of the ADIPOQ gene was genotyped in 438 subjects with angiographically diagnosed CAD and 443 controls. Levels of serum adiponectin were determined in 152 CAD subjects and 155 controls. Results The CAD subjects had GT and TT genotypes more frequently, and had GG genotype less frequently than the controls. The OR increased and was significant after adjustment for known CAD risk factors. Significant difference was also observed with T allele being more frequent among the CAD subjects. The T allele at the rs1501299 polymorphism was associated with a higher risk of CAD. The mean adiponectin levels of CAD patients were lower than control subjects. No significant correlation was seen of different genotypes with serum adiponectin levels. Conclusions The adiponectin rs1501299 G>T variant was positively related with an increased risk of CAD, and the CAD patients had lower adiponectin levels which were not affected by the different genotypes of rs1501299 in the present study. |
| Databáze: | OpenAIRE |
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