Age-dependent sexual dimorphism in hippocampal cornu ammonis-1 perineuronal net expression in rats
| Autor: | Susan L. Zup, Brian B. Griffiths, Amanda M. K. Madden, Kimbra A. Edwards, Creed M. Stary |
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| Rok vydání: | 2018 |
| Předmět: |
Male
hippocampus extracellular matrix Hippocampus Hippocampal formation 050105 experimental psychology 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine medicine Animals 0501 psychology and cognitive sciences Zebra finch CA1 Region Hippocampal Original Research Sex Characteristics Neocortex biology Behavior Animal interneurons Perineuronal net 05 social sciences Age Factors Immunohistochemistry Temporal Lobe Rats Sexual dimorphism medicine.anatomical_structure Parvalbumins nervous system biology.protein Female Neuron Neuroscience 030217 neurology & neurosurgery Parvalbumin |
| Zdroj: | Brain and Behavior |
| ISSN: | 2162-3279 |
| Popis: | Introduction Perineuronal nets (PNNs) are extracellular matrices that encompass parvalbumin‐expressing parvalbumin positive (PVALB+) fast‐spiking inhibitory interneurons where they protect and stabilize afferent synapses. Recent observations that gonadal hormones influence PVALB+ neuron development suggest that PNN regulation may be sexually dimorphic. Sex differences in PNN abundance and complexity have been reported in sexually dimorphic nuclei in zebra finch brains; however, corresponding differences in mammalian brains have not been investigated. Methods In this study we assessed the number of cortical and hippocampal PNNs in juvenile and young adult male and female rats using fluorescent immunohistochemistry for PVALB and the PNN marker Wisteria Floribunda Lectin. Results We report here that PNNs are numerous and well developed in hippocampal cornu ammonis‐1 of adult males but are lower in juvenile and possibly adult females. No significant differences were observed between sexes in cornu ammonis‐3 or adjacent neocortex. There was an observed developmental difference in the neocortex as juveniles had more PVALB+ cells, but fewer PNN+ cells, than adults. Conclusions Because PNNs are integral for several hippocampal‐mediated learning and memory tasks, these observations have potential sex‐dependent translational implications for clinical strategies targeting cognitive dysfunction. |
| Databáze: | OpenAIRE |
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