The effects of local irradiation on circulating lymphocytes in dogs receiving fractionated radiotherapy
| Autor: | Alain P Theon, Robert B. Rebhun, Katherine S. Hansen, Shaheen Emami, Michael S. Kent, Ellen E. Sparger |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Lymphocyte Gastroenterology Dogs Neoplasms Internal medicine medicine Adjuvant therapy Animals Dog Diseases Lymphocyte Count Lymphocytes Retrospective Studies General Veterinary medicine.diagnostic_test business.industry Cancer Complete blood count Immunosuppression Retrospective cohort study medicine.disease Combined Modality Therapy Radiation therapy Treatment Outcome medicine.anatomical_structure Local irradiation Female Dose Fractionation Radiation business |
| Zdroj: | Veterinary and Comparative Oncology. 18:191-198 |
| ISSN: | 1476-5829 1476-5810 |
| Popis: | Localized radiation therapy can be an effective treatment for cancer but is associated with localized and systemic side effects. Several studies have noted changes in complete blood count (CBC) parameters including decreases in the absolute lymphocyte count (ALC) and increases in the neutrophil:lymphocyte ratio (NLR). These changes could reflect immunosuppression and may contribute to decreased efficacy of immunotherapies used to treat cancer. We hypothesized that dogs would demonstrate decreased ALCs during a course of radiotherapy. A retrospective study was conducted on 203 dogs receiving definitive-intent radiotherapy. Demographic information, CBC values and details of the radiotherapy protocol were collected. The mean lymphocyte count pre-treatment was 1630.68 cells/μL (SD ± 667.56) with a mean NLR of 3.66 (SD ± 4.53). The mean lymphocyte count mid-treatment was 1251.07 cells/μL (SD ± 585.96) and the mean NLR was 6.23 (SD ± 4.99). There was a significant decrease in the mean lymphocyte count by 351.41 lymphocytes/μL (SD ± 592.32) between pre-treatment and mid-treatment (P |
| Databáze: | OpenAIRE |
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