Treatment of intimal sarcoma of peripheral veins
Autor: | D.Y. Garcia-Ortega, Mario Cuellar-Hubbe, Erwin R. Flores-Vazquez, Javier López-Gómez, Rodrigo Y. Adame, Ma. Alejandra Salazar-Álvarez |
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Rok vydání: | 2017 |
Předmět: |
medicine.medical_specialty
medicine.medical_treatment 030204 cardiovascular system & hematology Undifferentiated Pleomorphic Sarcoma 03 medical and health sciences 0302 clinical medicine Intimal sarcoma Medicine Case Series Vein Cephalic vein Lung business.industry Metastasectomy Chemoradiotherapy medicine.disease Radiation therapy Limp sparing surgery medicine.anatomical_structure Intimal sarcoma of peripheral veins 030220 oncology & carcinogenesis Surgery Radiology Sarcoma business |
Zdroj: | International Journal of Surgery Case Reports |
ISSN: | 2210-2612 |
DOI: | 10.1016/j.ijscr.2017.01.018 |
Popis: | Highlights • Intimal sarcoma is an extremely rare group. • Intimal sarcoma of large veins even rarer information and case reports are limited. • Unique case in the medical literature and the best current evidence in the biological behavior and the response of the multiple options of treatment in this type of tumors. Introduction Intimal sarcoma is an extremely rare group of undifferentiated pleomorphic sarcoma arising from the intimal layer of vessels accounting for only 1% of all sarcomas, intimal sarcoma of large veins are even less common. Cases presentation We present two cases of intima sarcoma, one originated form the basilar vein and the other from the cephalic vein, the first one was treated with surgery and postoperative chemotherapy followed by Radiotherapy (RT), the second case was treated with isolated limb perfusion followed by marginal resection and RT. Both patients progressed to the lungs in a short time, the first case was treated with metastasectomy of the lung and is without evidence of disease 7 months after surgery; the second case treated with isolated limb perfusion has stable disease. Discussion Intimal sarcoma are very aggressive tumors, with a high metastatic potential, the two patients progressed to lung in a short time (2 months) after local treatment. Both cases exhibit good response to chemotherapy and metastasectomy with a disease – free period of 7 months. Conclusion We propose that given the aggressive behavior of these tumors, they should be treated with chemoradiotherapy postoperative, either by systemic chemotherapy or isolated limb perfusion for the limp sparing surgery in this histology. |
Databáze: | OpenAIRE |
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