Dysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with Intellectual Disability and Autism
| Autor: | Carmela Maria Bonaccorso, Michela Spatuzza, Maria Vincenza Catania, Ferdinando Nicoletti, Lucia Ciranna, Ferdinando NICOLETTI, Simona D'Antoni, Sebastiano Antonino Musumeci, Kimberly Huber |
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| Rok vydání: | 2014 |
| Předmět: |
PTEN
SHANK Neuroligin Receptor Metabotropic Glutamate 5 Cognitive Neuroscience autism Receptors Metabotropic Glutamate Synaptic plasticity Article Behavioral Neuroscience mental retardation fragile x tsc neuroligin homer developmental disorders shank fmrp sapap3 pten synaptic plasticity Intellectual Disability Intellectual disability medicine Animals Humans SAPAP3 mGluR1 Autistic Disorder Fmrp mGluR5 TSC Neuronal Plasticity Developmental disorders Glutamate receptor Mental retardation medicine.disease Fragile X syndrome Homer Neuropsychology and Physiological Psychology Metabotropic receptor Metabotropic glutamate receptor Fragile X Syndrome Fragile X Autism Psychology Neuroscience Signal Transduction |
| Zdroj: | Neuroscience and biobehavioral reviews 46 (2014): 228–241. doi:10.1016/j.neubiorev.2014.02.003 info:cnr-pdr/source/autori:D'Antoni S.; Spatuzza M.; Bonaccorso C.M.; Musumeci S.A.; Ciranna L.; Nicoletti F.; Huber K.M.; Catania M.V./titolo:Dysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with Intellectual Disability and Autism/doi:10.1016%2Fj.neubiorev.2014.02.003/rivista:Neuroscience and biobehavioral reviews/anno:2014/pagina_da:228/pagina_a:241/intervallo_pagine:228–241/volume:46 |
| ISSN: | 0149-7634 |
| DOI: | 10.1016/j.neubiorev.2014.02.003 |
| Popis: | Activation of group-I metabotropic glutamate receptors, mGlu1 and mGlu5, triggers a variety of signalling pathways in neurons and glial cells, which are differently implicated in synaptic plasticity. The earliest and much of key studies discovered abnormal mGlu5 receptor function in Fragile X syndrome (FXS) mouse models which then motivated more recent work that finds mGlu5 receptor dysfunction in related disorders such as intellectual disability (ID), obsessive-compulsive disorder (OCD) and autism. Therefore, mGlu1/5 receptor dysfunction may represent a common aetiology of these complex diseases. Furthermore, many studies have focused on dysregulation of mGlu5 signalling to synaptic protein synthesis. However, emerging evidence finds abnormal mGlu5 receptor interactions with its scaffolding proteins in FXS which results in mGlu5 receptor dysfunction and phenotypes independent of signalling to protein synthesis. Finally, both an increased and reduced mGlu5 functioning seem to be associated with ID and autism spectrum disorders, with important consequences for potential treatment of these developmental disorders. |
| Databáze: | OpenAIRE |
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