| Autor: |
Yutaka Yasui, Daniel M. Green, Leslie L. Robison, Melissa M. Hudson, Jinghui Zhang, Fred B. Berry, Matthew J. Krasin, Wassim Chemaitilly, Zhaoming Wang, Rikeenkumar Dhaduk, Jessica Baedke, Qi Liu, Lu Lu, Klementina Fon Tacer, Wonjong Moon, Asifa K. Zaidi, Carmen L. Wilson, Yadav Sapkota |
| Rok vydání: |
2023 |
| DOI: |
10.1158/0008-5472.22425636.v1 |
| Popis: |
Sup Table 1: Age-adjusted testosterone, FSH and LH levels in community controls. Sup Table 2: Non-genetic model for sperm concentration (millions/mL) among 201 unirradiated male survivors who were exposed to CED. Sup Table 3: Sperm characteristics in oligospermic and normospermic semen analysis participants in the discovery sample. Sup Table 4: Rare variant associations for sperm concentration (millions/mL) showing statistical significance in standard burden and SKAT tests and their results based on permutation-based analyses. Sup Table 5: Meta-analysis of discovery and replications results for the chromosome 7q21.3 locus associated with sperm concentration. Sup Table 6: The association of rs7784118 with sperm concentration in the discovery sample, stratified by endocrine parameters. Sup Table 7: Consistency of two different semen analyses for the 16 male survivors in the discovery sample. Sup Figure 1: Principal component analysis (PCA) of survivors in the SJLIFE WGS dataset. Sup Figure 2: Quantile-quantile plot for the common variant analysis of sperm concentration in the discovery sample. Sup Figure 3: Distribution of sperm concentration (millions/mL) with respect to genotypes of rs7784118 in the discovery cohort. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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