Intestinal Integrity Biomarkers in Early Antiretroviral-Treated Perinatally HIV-1–Infected Infants
| Autor: | Adriana Weinberg, Myron J. Levin, Wei Li Adeline Koay, Priyanka Uprety, Deborah Persaud, Mutsa Bwakura-Dangarembizi, Jane C. Lindsey |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cholera Toxin Human immunodeficiency virus (HIV) HIV Infections Inflammation Fatty Acid-Binding Proteins medicine.disease_cause Fatty acid-binding protein Major Articles and Brief Reports 03 medical and health sciences Double-Blind Method Pregnancy medicine Humans Immunology and Allergy Protein Precursors Demography Haptoglobins business.industry Infant Zonulin Intestines Breast Feeding 030104 developmental biology Infectious Diseases Anti-Retroviral Agents Intestinal Fatty Acid-Binding Protein Immunology HIV-1 Biomarker (medicine) Female medicine.symptom business Breast feeding Biomarkers Immune activation |
| Zdroj: | The Journal of Infectious Diseases. 218:1085-1089 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Intestinal fatty acid binding protein (iFABP) levels did not differ between human immunodeficiency virus type 1 (HIV-1)– infected infants and uninfected infants exposed to HIV-1, but those who breastfed had substantially lower levels. Zonulin levels increased from 3 to 5.3 months of age with perinatal acquisition of HIV-1 despite early antiretroviral treatment. Biomarkers of intestinal integrity (ie, iFABP and zonulin) were compared in 56 HIV-1–positive African infants who received early antiretroviral treatment and 53 HIV-1–exposed but uninfected (HEU) controls. Despite heightened inflammation and immune activation in HIV-positive infants, iFABP and zonulin levels at 3 months of age were not different from those in HEU infants and largely were not correlated with inflammatory and immune activation biomarkers. However, zonulin levels increased and became significantly higher in HIV-positive infants as compared to HEU infants by 5 months of age, despite viral suppression due to antiretroviral treatment. These findings have implications for intestinal integrity biomarker profiling in perinatal HIV-1 infection. |
| Databáze: | OpenAIRE |
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