PTPN22 R620W genotype-phenotype correlation analysis and gene-environment interaction study in early rheumatoid arthritis: results from the ESPOIR cohort
| Autor: | Salliot, Carine, Dawidowicz, Karen, Lukas, Cédric, Guedj, Mickael, Paccard, Caroline, Benessiano, Joelle, Dougados, Maxime, Nicaise, Pascale, Meyer, Olivier, Dieudé, Phillippe, Saraux, Alain |
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| Přispěvatelé: | Hôpital Lariboisière, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Département de Rhumatologie[Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, 'Cartes d'Identité des Tumeurs ' program (CIT), Ligue Nationale Contre le Cancer, Department of Biostatistics, Pharnext, privé, CIC - CHU Bichat, Institut National de la Santé et de la Recherche Médicale (INSERM), Service de rhumatologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service Rhumatologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Immunologie et Pathologie (EA2216), Université de Brest (UBO)-IFR148, Centre d'Investigation Clinique (CIC - Brest), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), Merck Sharp, Dohme (MSD), INSERM, French Society of Rheumatology, Abbott, Wyeth, Assistance publique - Hôpitaux de Paris (AP-HP) - Hôpital Lariboisière - Université Paris Diderot - Paris 7 (UPD7), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier) - Hôpital Lapeyronie, Assistance publique - Hôpitaux de Paris (AP-HP) - CHU Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) - AP-HP - Hôpital Bichat - Claude Bernard [Paris] - Université Paris Diderot - Paris 7 (UPD7), Université de Brest (UBO) - IFR148, Université de Brest (UBO) - Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Lariboisière-Université Paris Diderot - Paris 7 (UPD7), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris]-Université Paris Diderot - Paris 7 (UPD7) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Oncology
Male [SDV]Life Sciences [q-bio] SHARED EPITOPE ALLELES MESH : Genotype PROGRESSION Logistic regression Arthritis Rheumatoid Cohort Studies MESH: Genotype 0302 clinical medicine Risk Factors MESH : Peptides Cyclic MESH: Risk Factors Pharmacology (medical) MESH : Female 030212 general & internal medicine Gene–environment interaction MESH: Protein Tyrosine Phosphatase Non-Receptor Type 22 MESH: Cohort Studies MESH: Arthritis Rheumatoid MESH : Estrogen Replacement Therapy MESH: Middle Aged MESH: Polymorphism Single Nucleotide Confounding Estrogen Replacement Therapy MESH : Polymorphism Single Nucleotide Smoking Absolute risk reduction Cohort MESH: Genetic Predisposition to Disease ASSOCIATION Middle Aged MESH : Risk Factors MESH : Environment 3. Good health MESH : Rheumatoid Factor [SDV] Life Sciences [q-bio] MESH : Phenotype Phenotype HLA-DRB1 Rheumatoid arthritis Female REPLACEMENT medicine.medical_specialty MESH: Rheumatoid Factor Genotype MESH : Male MESH : Cohort Studies Environment CAUCASIAN POPULATION MESH: Phenotype Peptides Cyclic Polymorphism Single Nucleotide PTPN22 03 medical and health sciences Rheumatology Rheumatoid Factor Internal medicine medicine Humans Genetic Predisposition to Disease MESH : Middle Aged Hormonal treatments MESH: Environment METAANALYSIS MESH: Peptides Cyclic 030203 arthritis & rheumatology MESH: Humans business.industry Early RA MESH : Humans MESH: Biological Markers Protein Tyrosine Phosphatase Non-Receptor Type 22 Odds ratio medicine.disease MESH: Estrogen Replacement Therapy POLYMORPHISM MESH: Male MESH : Biological Markers PTPN22 620W MESH : Protein Tyrosine Phosphatase Non-Receptor Type 22 Immunology MESH : Arthritis Rheumatoid RISK MESH : Genetic Predisposition to Disease CIGARETTE-SMOKING business MESH: Female Biomarkers |
| Zdroj: | Rheumatology Rheumatology, Oxford University Press (OUP), 2011, 50 (10), pp.1802-8. ⟨10.1093/rheumatology/ker224⟩ Rheumatology, Oxford University Press (OUP), 2011, 50 (10), pp.1802-8. 〈10.1093/rheumatology/ker224〉 |
| ISSN: | 1462-0324 1460-2172 |
| DOI: | 10.1093/rheumatology/ker224⟩ |
| Popis: | International audience; OBJECTIVES: To investigate genotype-phenotype correlation and gene-environment interaction between PTPN22 R620W environmental factors such as tobacco/hormonal treatments in an inception cohort of RA patients. METHODS: An intra-cohort study including 532 Caucasian RA patients genotyped for the PTPN22 rs2476601 polymorphism was performed. Anti-CCP and RF status at baseline, presence of bone erosions at 1 year, HLADR1 and/or DR4 status, demography, comorbidities, exposure to tobacco with the cumulative dose in pack-years, hormonal treatments and treatments received for RA were collected. Logistic regression was performed to estimate the ORs and multiplicative interaction with adjustment for confounding factors. Gene-environment interaction was estimated by the relative excess risk due to interaction (RERI), attributable proportion (AP) and synergy index (SI). RESULTS: PTPN22 620W risk allele was associated with ACPA production [odds ratio (OR) = 2.21, 95% CI 1.4, 3.4, P |
| Databáze: | OpenAIRE |
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