Survival of patients with neuroendocrine carcinoma of the colon and rectum: a population-based analysis
| Autor: | Shihab Ali, Adam J. Olszewski, Mohammed Salhab, Hammad Shafqat |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Oncology
Male medicine.medical_specialty Population Adenocarcinoma Sex Factors Internal medicine Outcome Assessment Health Care medicine Carcinoma Humans Registries education Survival analysis Colectomy Aged Neoplasm Staging education.field_of_study Relative survival business.industry Rectal Neoplasms Incidence (epidemiology) Gastroenterology Age Factors Cancer Disease Management General Medicine medicine.disease Prognosis Combined Modality Therapy Survival Analysis United States Carcinoma Neuroendocrine Socioeconomic Factors Population Surveillance Colonic Neoplasms Female Neoplasm Grading business Colorectal Neuroendocrine Carcinoma |
| Zdroj: | Diseases of the colon and rectum. 58(3) |
| ISSN: | 1530-0358 |
| Popis: | BACKGROUND High-grade neuroendocrine carcinoma is a rare colorectal pathology described in a case series. The role of surgery in this disease has been questioned. OBJECTIVE The purpose of this work was to describe the incidence, management, and outcomes of neuroendocrine carcinoma in comparison with high-grade adenocarcinoma. DESIGN This was a retrospective, population-based outcomes research study. SETTINGS The Survey of Epidemiology and End Results database was used. PATIENTS A total of 1367 patients with colorectal neuroendocrine carcinoma (distinguishing small-cell and non-small-cell subtypes) and 72,533 with high-grade adenocarcinoma diagnosed between 2000 and 2011 were included in this study. INTERVENTIONS Resection of the primary tumor was the main intervention. MAIN OUTCOME MEASURES Median overall and 5-year relative survival were measured. Trends were expressed as the annual percent change in incidence and relative survival. RESULTS The incidence rate increased for neuroendocrine carcinoma (annual percent change, +2.2%; p =0.035) and decreased for high-grade adenocarcinoma (annual percent change, -3.1%; p < 0.00001) during the study period. Relative survival at 5 years in neuroendocrine carcinoma was 16.3% overall and 57.4%, 56.4%, 26.3%, and 3.0% for stages I, II, III, and IV cancer. Small-cell tumors had worse survival (10% versus 19% for non-small cell). There was no improvement in the relative survival for neuroendocrine carcinoma (annual percent change, -1.1%; p =0.06) in contrast to adenocarcinoma (annual percent change, +0.7%; p < 0.00001). Patients with localized non-small-cell neuroendocrine carcinoma had better overall survival with surgery (median, 21 months) than without (6 months; log-rank, p < 0.0001), whereas those with small-cell neuroendocrine carcinoma did not (18 versus 14 months; p = 0.95). Prognosis in resected neuroendocrine carcinoma was worse with an increasing number of metastatic lymph nodes. LIMITATIONS Histology and grade assignments were not centrally verified. Data on chemotherapy use, patient performance status, and comorbidities were unavailable. CONCLUSIONS Neuroendocrine carcinoma did not benefit from advances in the prevention and treatment of colorectal adenocarcinoma over the past decade. Relatively poor survival in early stage neuroendocrine carcinoma warrants studies of adjuvant systemic therapy. The differences in outcomes between small-cell and non-small-cell neuroendocrine carcinomas indicate a need for histology-specific management. |
| Databáze: | OpenAIRE |
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