Estrogens in vascular biology and disease: where do we stand today?
| Autor: | Pierre Gourdy, Jean-François Arnal, Florence Trémollières, Henrik Laurell, Pierre-Yves Scarabin |
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| Přispěvatelé: | Institut de médecine moléculaire de Rangueil (I2MR), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-IFR150-Institut National de la Santé et de la Recherche Médicale (INSERM), Recherche en épidémiologie et biostatistique, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Sud - Paris 11 (UP11), Simon, Marie Francoise, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées- Institut Fédératif de Recherche Bio-médicale Institution (IFR150)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism medicine.medical_treatment Physiology Disease 030204 cardiovascular system & hematology Biology Nitric Oxide MESH: Estrogens MESH: Atherosclerosis 03 medical and health sciences 0302 clinical medicine Epidemiology Genetics medicine Animals Humans MESH: Animals Vascular Diseases MESH: Thrombosis Molecular Biology Stroke 030304 developmental biology 0303 health sciences MESH: Humans Nutrition and Dietetics Fatty streak Vascular biology Estrogens Thrombosis Cell Biology Atherosclerosis medicine.disease 3. Good health Atheroma Receptors Estrogen MESH: Nitric Oxide Immunology MESH: Vascular Diseases MESH: Receptors Estrogen Endothelium Vascular MESH: Endothelium Vascular Hormone therapy Cardiology and Cardiovascular Medicine |
| Zdroj: | Current Opinion in Lipidology Current Opinion in Lipidology, Lippincott, Williams & Wilkins, 2007, 18 (5), pp.554-60. ⟨10.1097/MOL.0b013e3282ef3bca⟩ Current Opinion in Lipidology, 2007, 18 (5), pp.554-60. ⟨10.1097/MOL.0b013e3282ef3bca⟩ |
| ISSN: | 0957-9672 |
| DOI: | 10.1097/mol.0b013e3282ef3bca |
| Popis: | International audience; PURPOSE OF REVIEW: Whereas hormone therapy may increase the risk of coronary heart disease and stroke in menopausal women, epidemiological studies (protection in premenopausal women) suggest and experimental studies (prevention of fatty streak development in animals) demonstrate a major atheroprotective action of estradiol. There is also evidence for a thrombogenic effect of oral estrogens. An understanding of the deleterious and beneficial effects of estrogens is thus required. RECENT FINDINGS: The immuno-inflammatory system plays a key role in the development of fatty streak deposit as well as in the rupture of the atherosclerotic plaque. Whereas estradiol favors an anti-inflammatory effect in vitro (cultured cells), it rather elicits a pro-inflammatory response in vivo involving several subpopulations of the immuno-inflammatory system, which could contribute to plaque destabilization. Endothelium is another important target for estrogens, since estradiol potentiates endothelial nitric oxide and prostacyclin production. The respective actions of estrogens on these cell populations may be influenced by the timing of hormonal therapy initiation, hormone regimens, status of the vessel wall and expression of isoforms of estrogen receptors alpha and beta. SUMMARY: A better understanding of the balance between the deleterious and beneficial effects of estrogens is required and should help to improve hormonal therapy safety and to optimize the prevention of cardiovascular disease after menopause. |
| Databáze: | OpenAIRE |
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