TRANSVAC workshop on standardisation and harmonisation of analytical platforms for HIV, TB and malaria vaccines: ‘How can big data help?’
| Autor: | Stefan H. E. Kaufmann, Jelle Thole, Carlos A. Guzmán, Helen A. Fletcher, Hans-Joachim Mollenkopf, Odile Leroy, Tom H. M. Ottenhoff, Mark J. Geels, Céline Dutruel |
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| Přispěvatelé: | Helmholtz Centre for Infection Research, Inhoffenstraße 7, 38124 Braunschweig, Germany. |
| Rok vydání: | 2014 |
| Předmět: |
Biomedical Research
Big data Human immunodeficiency virus (HIV) TRANSVAC medicine.disease_cause Protein expression 03 medical and health sciences 0302 clinical medicine Immunology and Microbiology(all) Malaria Vaccines medicine Tuberculosis Humans 030212 general & internal medicine Tuberculosis Vaccines 030304 developmental biology AIDS Vaccines 0303 health sciences General Veterinary General Immunology and Microbiology business.industry Harmonisation Comparability Vaccination Public Health Environmental and Occupational Health HIV Molecular analyses medicine.disease veterinary(all) 3. Good health Malaria Infectious Diseases Risk analysis (engineering) Infectious disease (medical specialty) Immunology Molecular Medicine Sample collection Standardisation business Biomarkers |
| Zdroj: | Vaccine, 32(35), 4365-4368 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2014.06.014 |
| Popis: | High-throughput analyses of RNA and protein expression are increasingly used for better understanding of vaccine-induced immunity and protection against infectious disease. With an increasing number of vaccine candidates in clinical development, it is timely to consider standardisation and harmonisation of sample collection, storage and analysis to ensure results of highest quality from these precious samples. These challenges were discussed by a group of international experts during a workshop organised by TRANSVAC, a European Commission-funded Research Infrastructure project. The main conclusions were: Platforms are rarely standardised for use in preclinical and clinical studies. Coordinated efforts should continue to harmonise the experimental set up of these studies, as well as the establishment of internal standards and controls. This will ensure comparability, efficiency and feasibility of the global analyses performed on preclinical and clinical data sets. |
| Databáze: | OpenAIRE |
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