Multimodal management of stages III-IVa malignant thymoma
| Autor: | M Sacco, Giuliano Maggi, Caterina Casadio, E Manzin, Luigi Dogliotti, G L Sannazzari, Alfredo Berruti, C Loddo, Francesco Ardissone, Paola Sperone, Piero Borasio, M. Tessa, S. Bretti, Gabriella Gorzegno |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male Cancer Research medicine.medical_specialty Thymoma Adolescent medicine.medical_treatment chemotherapy medicine Humans Progression-free survival Stage (cooking) Radical surgery Aged Neoplasm Staging Retrospective Studies Aged 80 and over Malignant Thymoma Univariate analysis business.industry Multimodal therapy Thymus Neoplasms Middle Aged medicine.disease Combined Modality Therapy Survival Analysis Surgery Radiation therapy Treatment Outcome Oncology Thymoma multidisciplinary approach chemotherapy multidisciplinary approach Female Radiotherapy Adjuvant business |
| Popis: | Purpose: The optimal therapy for locally advanced malignant thymoma is controversial. We review our experience with a multimodal approach in 63 consecutive cases. Patients and methods: Forty-three patients had stage III and 20 stage IVa disease. Surgery with radical intent was initially performed in 30 cases, while 33 cases not amenable to radical surgery underwent neoadjuvant treatment (radiotherapy in 8 and chemotherapy in 25) before surgical reassessment. All patients, whether or not surgically resected, received radiation therapy. Results: Radical resection (RR) was performed in 20 patients ab initio (all stage III) and in 12 patients after neoadjuvant treatment (eight stage III and four stage IVa). With the addition of patients radically operated with neoadjuvant treatment, the radical resection rate increased from 46 to 65% in stage III patients, and from 0 to 20% in those with stage IVa disease, respectively. Radical surgery was associated with longer progression free survival and overall survival according to both univariate analysis (P |
| Databáze: | OpenAIRE |
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