Cilengitide induces autophagy-mediated cell death in glioma cells
| Autor: | Cunli Xiang, Sandra A. Rempel, Tom Mikkelsen, Stephanie L. Lomonaco, Wei Jiang, Chaya Brodie, Nancy Lemke, Susan Finniss, Hae Kyung Lee |
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| Rok vydání: | 2011 |
| Předmět: |
Radiation-Sensitizing Agents
endocrine system Cancer Research Programmed cell death Blotting Western Transplantation Heterologous Cell Integrin Cilengitide Rats Nude chemistry.chemical_compound Cell Line Tumor Glioma Autophagy medicine Animals Humans Cytotoxic T cell Cell Proliferation biology Brain Neoplasms Cell growth medicine.disease Combined Modality Therapy Rats Cell biology medicine.anatomical_structure Oncology chemistry Gamma Rays Basic and Translational Investigations Neoplastic Stem Cells biology.protein Neurology (clinical) Snake Venoms |
| Zdroj: | Neuro-Oncology. 13:857-865 |
| ISSN: | 1523-5866 1522-8517 |
| DOI: | 10.1093/neuonc/nor073 |
| Popis: | We studied the effect of the integrin inhibitor cilengitide in glioma cells. Cilengitide induced cell detachment and decreased cell viability, and induction of autophagy followed by cell apoptosis. In addition, cilengitide decreased the cell renewal of glioma stem-like cells (GSCs). Inhibition of autophagy decreased the cytotoxic effect of cilengitide. Pretreatment of glioma cells and GSCs with cilengitide prior to γ-irradiation resulted in a larger increase in autophagy and a more significant decrease in cell survival. We found that cilengitide induced autophagy collectively in glioma cells, xenografts, and GSCs, which contributed to its cytotoxic effects and sensitized these cells to γ-radiation. |
| Databáze: | OpenAIRE |
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