Nitric oxide is not involved in the initiation of insulin secretion from rat islets of Langerhans
| Autor: | Shanta J. Persaud, J. D. Pearson, T. Bjaaland, Peter B. Jones, Simon L. Howell |
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| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism medicine.medical_treatment Biology Nitric Oxide Nitric oxide Islets of Langerhans chemistry.chemical_compound Internal medicine Insulin Secretion Dibutyryl Cyclic GMP Internal Medicine medicine Animals Insulin Secretion Rats Wistar Cyclic GMP Cyclic guanosine monophosphate Cells Cultured geography geography.geographical_feature_category Islet Rats Endocrinology chemistry Amino Acid Oxidoreductases Nitric Oxide Synthase Intracellular Hormone Endocrine gland |
| Zdroj: | Diabetologia. 35:1020-1027 |
| ISSN: | 1432-0428 0012-186X |
| Popis: | The involvement of nitric oxide as an intracellular messenger in the control of insulin secretion from pancreatic Beta cells was studied in rat islets of Langerhans by measuring: (i) nitric oxide generation in response to physiological insulin secretagogues; (ii) the effects of inhibitors of nitric oxide synthesis on insulin secretory responses to physiological secretagogues, and on insulin synthesis; (iii) changes in islet cyclic guanosine monophosphate in response to secretagogues; (iv) the effects of exogenous cyclic guanosine monophosphate and dibutyryl cyclic guanosine monophosphate on insulin secretion from electrically permeabilised islets and from intact islets, respectively. These studies produced no evidence that nitric oxide generation is required for the initiation of insulin secretion by common secretagogues. However, the results of our experiments suggest that the generation of nitric oxide may be involved in long-term, glucose-dependent increases in cyclic guanosine monophosphate content of islet cells, although the physiological relevance of these changes requires further investigation. |
| Databáze: | OpenAIRE |
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