High doses of antipsychotic polypharmacy are related to an increase in serum levels of pentosidine in patients with schizophrenia
| Autor: | Tomohito Gohda, Ayako Kimoto, Mayu Takeda, Yusuke Suzuki, Narimasa Katsuta, Eriko Tani, Heii Arai, Yuto Takebayashi, Nobuto Shibata, Shohei Nishimon, Ryoko Higashiyama, Toru Nakamura, Yasuhiko Tomino, Yasue Miki, Sho-ichi Yamagishi, Tohru Ohnuma, Takahiro Sannohe, Masayoshi Takeuchi |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Pharmacology Arginine Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Statistical significance Internal medicine Humans Medicine In patient Pentosidine Antipsychotic Biological Psychiatry Aged Polypharmacy business.industry Lysine Middle Aged medicine.disease 030227 psychiatry Cross-Sectional Studies chemistry Schizophrenia Cohort Female business 030217 neurology & neurosurgery Antipsychotic Agents Cohort study |
| Zdroj: | Progress in Neuro-Psychopharmacology and Biological Psychiatry. 76:42-48 |
| ISSN: | 0278-5846 |
| DOI: | 10.1016/j.pnpbp.2017.02.019 |
| Popis: | Background Carbonyl stress in patients with schizophrenia has been reported to be reflected by an increase in peripheral pentosidine levels. This cohort study tested whether the accumulation of pentosidine was related to the disease severity or the treatment (routine administration of high antipsychotic doses). Methods We followed up our original investigation using a new group of 137 patients with acute schizophrenia and 45 healthy subjects, and then pooled the two cohorts to conduct the following analysis on a total of 274 patients. The associations of serum pentosidine and pyridoxal levels with duration of education, estimated duration of medication, the severity of symptoms, and daily doses of antipsychotics, antiparkinsonian drugs, and anxiolytics were evaluated by multiple linear regression analysis. Results The combined cohort of 274 patients exhibited abnormally high serum levels of pentosidine, were associated with a higher daily dose of antipsychotic drugs and a longer estimated duration of medication without statistical significance of diagnosis. This was also observed in the patients treated with antipsychotic polypharmacy, but the serum pentosidine levels of patients treated with first- or second-generation antipsychotic monotherapy showed no relationship with these two variables. Conclusion High levels of serum pentosidine were associated with high daily doses of antipsychotic drugs and a longer estimated duration of medication in patients treated with antipsychotic polypharmacy. |
| Databáze: | OpenAIRE |
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