Cell mediated and antibody immune response to inactivated hepatitis A vaccine
Autor: | P. Schmidtke, Roland Sänger, Fred Zepp, Markus Knuf, P. Habermehl, C. U. Meyer |
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Rok vydání: | 2004 |
Předmět: |
Adult
Male Viral Hepatitis Vaccines Cellular immunity T cell Hepatitis A vaccine Immunization Secondary Biology Hepatitis A Antibodies Lymphocyte Activation Peripheral blood mononuclear cell Immune system Immunity medicine Humans Hepatitis A Vaccines Immunity Cellular General Veterinary General Immunology and Microbiology Public Health Environmental and Occupational Health Hepatitis A Virology Infectious Diseases medicine.anatomical_structure Vaccines Inactivated Humoral immunity Immunology biology.protein Molecular Medicine Female Antibody Hepatitis A Virus Human |
Zdroj: | Vaccine. 23(44) |
ISSN: | 0264-410X |
Popis: | The humoral and cellular immune response to inactivated hepatitis A vaccine was investigated dynamically in a time elapse study over 1 year. Fourty-five healthy volunteers, seronegative for anti-HAV, were vaccinated with 1440 enzyme-linked immunosorbent assay units (EU) of formalin-inactivated hepatitis A virus following a 0--6-month schedule. Serum anti-HAV levels and HAV-specific proliferation of peripheral blood mononuclear cells were measured at several time points over a 26- and 28-week period after the first and second injection, respectively. Distinct B and T cell responses were determined within 14 days after primary vaccination. The booster vaccination-induced immediate peak levels for the humoral (anti-HAV GMC=5376mIU/ml) as well as the cellular (median Deltacpm=14173cpm) response. |
Databáze: | OpenAIRE |
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