Impact of Androgen Deprivation Therapy on Non-Alcoholic Fatty Liver Disease in Patients with Prostate Cancer: A CT Evaluation
| Autor: | Yuichi Arai, Harutake Sawazaki, Yosuke Kitamura, Kota Yagi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Antineoplastic Agents Hormonal Urology 030232 urology & nephrology Computed tomography Disease Gastroenterology Androgen deprivation therapy 03 medical and health sciences Prostate cancer 0302 clinical medicine Non-alcoholic Fatty Liver Disease Internal medicine medicine Humans In patient skin and connective tissue diseases Aged Retrospective Studies Aged 80 and over medicine.diagnostic_test business.industry Fatty liver Prostatic Neoplasms Non alcoholic Middle Aged medicine.disease 030220 oncology & carcinogenesis Disease Progression sense organs Leuprolide Steatosis Tomography X-Ray Computed business Oligopeptides |
| Zdroj: | Urologia Internationalis. 104:425-430 |
| ISSN: | 1423-0399 0042-1138 |
| DOI: | 10.1159/000507351 |
| Popis: | Purpose: The aim of this study was to investigate the influence of androgen deprivation therapy (ADT) on the progression of non-alcoholic fatty liver disease (NAFLD) in patients with prostate cancer (PCa) by evaluation of hepatic steatosis on computed tomography (CT). Methods: The study included 77 PCa patients who underwent abdominal CT at baseline and after 6 months of ADT. The degree of hepatic steatosis was evaluated according to the attenuation value for liver parenchyma (CTLP), the attenuation ratio for liver and spleen (LSratio), and the difference in attenuation between LS (LSdif). The associations between these 3 indices and various metabolic syndrome-related factors were analyzed. Results: The number of NAFLD patients increased from 9 (11.6%) at baseline to 16 (20.7%) after ADT. The CTLP, LSratio, and LSdif values were significantly lower after ADT than before (p < 0.05). There were significant correlations between the percent change in CTLP and the percent change in HbA1c, between the percent change in LSratio and the percent change in abdominal circumference, and between the percent change in LSdif and the percent change in BMI. Conclusions: Six months of ADT was associated with significant progression of NAFLD in PCa patients. This progression was strongly correlated with changes in HbA1c, abdominal circumference, and BMI. |
| Databáze: | OpenAIRE |
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