Ifosfamide Chemotherapy and Nonconvulsive Status Epilepticus
| Autor: | Rikki Racela, Daniel Taupin, Daniel Friedman |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Midazolam
medicine.medical_treatment Status epilepticus Electroencephalography Diagnosis Differential Epilepsy Fatal Outcome Carcinosarcoma medicine Humans Ictal Ifosfamide Evoked Potentials Peritoneal Neoplasms Cerebral Cortex Chemotherapy medicine.diagnostic_test business.industry Signal Processing Computer-Assisted General Medicine Middle Aged medicine.disease Neurology Anesthesia Epilepsy Generalized Female Neurology (clinical) medicine.symptom business medicine.drug |
| Zdroj: | Clinical EEG and Neuroscience. 45:222-225 |
| ISSN: | 2169-5202 1550-0594 |
| DOI: | 10.1177/1550059413500777 |
| Popis: | We present a patient with peritoneal carcinosarcoma who was treated with the alkylating agent ifosfamide and experienced a rapid decline in mental status. Electroencephalogram (EEG) displayed generalized periodic epileptiform discharges, which raised suspicion for nonconvulsive status epilepticus (NCSE). Following administration of midazolam, the patient’s clinical condition and EEG improved. We review the 8 documented cases of ifosfamide-induced NCSE, and demonstrate the similarity in clinical features when compared with ifosfamide neurotoxicity that is not classified as NCSE. EEG findings suggesting an ictal pattern are subtle and heterogeneous, but they are essential for a diagnosis. Since it is unlikely that EEGs are uniformly obtained in instances of ifosfamide neurotoxicity, many cases of NCSE may go unrecognized. |
| Databáze: | OpenAIRE |
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