The preventive effect of ginkgo biloba extract in myringosclerosis: Study in rats
| Autor: | Kürşat Ceylan, Zeynep Kizilkaya Kaptan, Nuran Sungu, Hüseyin Üstün, Erdal Samim, Hatice Emir |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Tympanic Membrane Myringosclerosis medicine.medical_treatment Administration Oral Pharmacology Clinical study Tympanic Membranes Animals Medicine Rats Wistar Saline Dose-Response Relationship Drug Traditional medicine biology Plant Extracts business.industry Ginkgo biloba biology.organism_classification Rats Plant Leaves Otosclerosis Otorhinolaryngology Surgery business Phytotherapy |
| Zdroj: | Otolaryngology–Head and Neck Surgery. 140:171-176 |
| ISSN: | 1097-6817 0194-5998 |
| DOI: | 10.1016/j.otohns.2008.10.027 |
| Popis: | To determine the preventive effect of Ginkgo biloba extract in the formation of myringosclerosis.Prospective, randomized clinical study.Posterosuperior quadrant of tympanic membranes of twenty-five Wistar Albino rats were bilaterally myringotomized. They were divided into three groups randomly. Groups 1 and 2 were administered 100 mg/kg/day and 200 mg/kg/day systemic Ginkgo biloba extract. The third group was treated with 1 mL/day saline solution. After 10 days of treatment, myringotomized membranes were examined by otomicroscopy and harvested. They were evaluated histopathologically by light microscopy and compared according to the occurrence of myringosclerotic plaques and the thickness of membranes.Tympanic membranes of groups 1 and 2 nearly had no existence of myringosclerosis (72.2% in group 1 and 83.3% in group 2, P = 0.434). However, in group 3, only 14.3 percent had no myringosclerosis (P0.001). Thickness of membranes in group 1 was 0.13 +/- 0.25, group 2 was 0.06 +/- 0.02, and group 3 was 0.19 +/- 0.35 mm. Group 3 had significantly thicker membranes compared with groups 1 and 2 (P0.001 for group 2 and P = 0.003 for group 1).Formation of experimental myringosclerosis was reduced or inhibited and tympanic membranes were thinner after systemic Ginkgo biloba extract administration. |
| Databáze: | OpenAIRE |
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