EFFECTS OF SUBCHRONIC INHALATION OF VAPORIZED PLASTIC CEMENT ON EXPLORATORY BEHAVIOR AND PURKINJE CELL DIFFERENTIATION IN THE RAT
| Autor: | Héctor Figueroa, Rodrigo Pascual, Viancos L, Salgado C |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Cerebellum
Pathology medicine.medical_specialty Purkinje fibers Cellular differentiation Purkinje cell Toxicology Rats Sprague-Dawley Plastic cement Purkinje Cells Adhesives Administration Inhalation medicine Animals Cerebellar Purkinje cell differentiation Inhalation Chemistry Body Weight technology industry and agriculture Dendrites Anatomy Pollution Animals Suckling Rats medicine.anatomical_structure Exploratory Behavior Cerebellar vermis Female |
| Zdroj: | Journal of Toxicology and Environmental Health. 49:525-532 |
| ISSN: | 0098-4108 |
| DOI: | 10.1080/009841096160736 |
| Popis: | In the present study, the effects of preweaning cement vapor inhalation on exploratory behavior and cerebellar Purkinje cell differentiation were assessed. Sprague-Dawley albino rats were daily exposed to glue vapors between postnatal d 2 and 21. At postnatal d 22, all animals were submitted to the open-field test in order to evaluate their exploratory behavior. Then they were sacrificed, their brains dissected out, and cerebella stained according to the Golgi-Cox-Sholl procedure. Purkinje cells sampled from parasagittal sections of the cerebellar vermis were drawn under camera lucida and their dendritic domain was determined. The collected data indicate that glue solvent inhalation impairs both Purkinje cell differentiation and locomotor exploratory behavior. |
| Databáze: | OpenAIRE |
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