Cyclosporine A blood concentration during pregnancy in renal allograft recipients
| Autor: | Kozłowska-Boszko B, A. Serafinowicz, Marek Durlik, J. Majchrzak, Mieczyslaw Lao, W Rowinski, Zbigniew Gaciong |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Nephrology medicine.medical_specialty Urology Azathioprine Hematocrit Pregnancy Internal medicine medicine Humans Kidney transplantation Transplantation Hematology medicine.diagnostic_test business.industry medicine.disease Kidney Transplantation Surgery Cyclosporine Renal allograft Prednisolone Female business Immunosuppressive Agents medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1432-2277 0934-0874 |
| DOI: | 10.1007/s001470050434 |
| Popis: | Pregnancy-induced changes increase hazards associated with cyclosporine (CsA) treatment. Blood CsA trough levels (C0) were estimated in 15 pregnant renal allograft recipients treated with prednisolone + CsA + azathioprine using the TDx Abbott fluorescent polarization immunoassay. Despite therapeutical dose levels of CsA administered during pregnancy (3.52-3.67 and 3.59 mg/kg body weight in the first, second, and third trimesters, respectively), C0 significantly decreased (first trimester 130.8 +/- 36.9, second 92.0 +/- 32.7, and third 99.0 +/- 36.9 ng/ml). The mean increase of patient's body weight in mid-pregnancy was 3.0 +/- 2.19 kg and was associated with a significant (P0.05) fall in a hematocrit value (from 42 +/- 4.9% prior to pregnancy to 34 +/- 6% at the 20th week). We postulate that C0 concentration does not reflect the true exposure to CsA as no episodes of acute graft rejection were observed during pregnancy. |
| Databáze: | OpenAIRE |
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