The non-coding RNAs of the H19-IGF2 imprinted loci: A focus on biological roles and therapeutic potential in Lung Cancer
| Autor: | Imad Matouk, Michal Gilon, David Halle, Abraham Hochberg |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Lung Neoplasms
Carcinogenesis Review miR-675 Oncomirs Biology medicine.disease_cause General Biochemistry Genetics and Molecular Biology law.invention Genomic Imprinting law microRNA medicine Animals Humans Lung cancer Gene Medicine(all) Genetics H19 Biochemistry Genetics and Molecular Biology(all) IGF2 RNA General Medicine medicine.disease MicroRNAs Genetic Loci Suppressor RNA Long Noncoding Genomic imprinting Function (biology) Imprinted cluster |
| Zdroj: | Journal of Translational Medicine |
| ISSN: | 1479-5876 |
| Popis: | Since it was first described, the imprinted cluster 11p15.5 has been reported to be deregulated in a variety of pediatric and adult cancers including that of the lung. Both protein coding and non-coding genes functioning as oncogenes or as tumor suppressor genes reside within this cluster. Oncomirs that can function as oncogenes or as tumor suppressors have also been reported. While a complete account of the role played by the 11p15.5 imprinted cluster in lung cancer is beyond the scope of this review, we will focus on the role of the non-coding RNAs processed from the H19-IGF2 loci. A special emphasis will be given to the H19/miR-675 gene locus. Their potential diagnostic and therapeutic use in lung cancer will be described. |
| Databáze: | OpenAIRE |
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