Signet ring cell features with peritoneal carcinomatosis in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy are associated with poor overall survival
| Autor: | Daniel M. Labow, Deepa R. Magge, Natasha DeNicola, Peter H. Liu, Benjamin J. Golas, Umut Sarpel, Daniel Solomon, Samantha N. Aycart, Daniela Feingold |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Colorectal cancer Population New York Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine otorhinolaryngologic diseases medicine Humans education Survival rate Peritoneal Neoplasms Aged Gastrointestinal Neoplasms Retrospective Studies education.field_of_study Signet ring cell business.industry Cancer Cytoreduction Surgical Procedures Hyperthermia Induced General Medicine Middle Aged Prognosis medicine.disease Peritoneal carcinomatosis Oncology 030220 oncology & carcinogenesis Conventional PCI Female 030211 gastroenterology & hepatology Surgery Hyperthermic intraperitoneal chemotherapy business Carcinoma Signet Ring Cell |
| Zdroj: | Journal of Surgical Oncology. 119:758-765 |
| ISSN: | 1096-9098 0022-4790 |
| Popis: | Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is effective in select patients with peritoneal carcinomatosis (PC). Signet ring cell (SRC) pathology is associated with poor prognosis. The role of CRS/HIPEC in this population is unclear.Patients diagnosed with PC due to appendiceal (AC), colorectal (CRC), and gastric cancer (GC) undergoing CRS/HIPEC 2007-2016 were included.A total of 268 patients were referred for CRS/HIPEC. Of the 204 patients who underwent complete CRS/HIPEC, 101 (49.5%) had AC, 85 (41.7%) CRC, and 18 (8.8%) GC. Patients with GC had higher rates of SRC pathology than AC and CRC: 12 (66.7%) vs 16 (15.8%) and 10 (11.7%). The 3-year survival rate after CRS/HIPEC was 5.7% for the SRC group and 66.1% for the non-SRC group (P 0.001). This was true for both AC and CRC subgroups (P 0.001 for both). Overall, patients with SRC were more likely to have a peritoneal carcinomatosis index (PCI) score 15 (P = 0.046). Upon multivariate analysis of the SRC population, PCI 20 (P = 0.007) and GC (P = 0.008) were found to be independent predictors of poor overall survival.Performing CRS/HIPEC for PC from gastrointestinal malignancies presenting SRC features is recommended on patients with select diseases of appendiceal and colorectal origins. |
| Databáze: | OpenAIRE |
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