Serum proteins and work habits in a group of farm-workers exposed to EBDCs

Autor:	Flavia Porreca, Renato Polimanti, Maria Barone, Maria Fuciarelli, Sara Piacentini
Rok vydání:	2010
Předmět:	Adult Aging Physiology Epidemiology Urine Ethylenethiourea Biology Settore BIO/08 Ethylenebis(dithiocarbamates) Blood serum Gene Frequency Environmental health Occupational Exposure Genetic variation Genetics Humans Genetic variability Haptoglobins business.industry Vitamin D-Binding Protein Smoking Public Health Environmental and Occupational Health Transferrin Agriculture Feeding Behavior Pesticide Blood proteins Biotechnology Fungicides Industrial Case-Control Studies alpha 1-Antitrypsin Population study Isoelectric Focusing business
Zdroj:	Annals of human biology. 37(3)
ISSN:	1464-5033
Popis:	Study of the association between genetic variability and individual susceptibility can help to characterize occupational or environmental risks due to xenobiotics.This study evaluates the influence of genetic components and environmental factors in relation to pesticide exposure.The study population consisted of 37 non-occupationally exposed workers and 74 farm-workers exposed to pesticide. Exposure was assessed through the measurement of urine concentration of ethylenethiourea (ETU). Genetic differences in drug metabolism were detected by a qualitative variability in serum proteins. The environmental factors were recorded by using a questionnaire.The results show a difference between ETU levels in farm-workers and in non-occupationally exposed workers. In the non-exposed group a relationship between ETU urinary concentration and lifestyle habits is present. In farm-workers ETU urinary concentration is less correlated with lifestyle habits, but is associated, rather, with their work. In the exposed individuals the serum protein analyses show a possible link between ETU urinary concentration and the polymorphism of group-specific component (Gc).The association between Gc polymorphism and ETU urinary concentration of subjects exposed to EBDCs could be due to the immunological function of Gc and the effects on the immune system of EBDCs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239317e61064dafbe6e200c010f6cf3a https://pubmed.ncbi.nlm.nih.gov/20377494 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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