Association of copy number variation in the FCGR3B gene with risk of autoimmune diseases
| Autor: | Juan-Manuel Anaya, Sunil K. Ahuja, Weijing He, Manju Mamtani |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Risk
Immunology Gene Dosage Single-nucleotide polymorphism Biology GPI-Linked Proteins medicine.disease_cause CCL3L1 Gene Autoimmune Diseases Autoimmunity Genetics medicine Humans Lupus Erythematosus Systemic Copy-number variation CCL3L1 Allele Genetics (clinical) Receptors IgG FCGR3B Sjogren's Syndrome Chemokines CC FCGR3B Gene Disease Susceptibility |
| Zdroj: | Genes & Immunity. 11:155-160 |
| ISSN: | 1476-5470 1466-4879 |
| DOI: | 10.1038/gene.2009.71 |
| Popis: | Copy number variation (CNV) in the human genome is an important determinant of susceptibility to autoimmune diseases. Many autoimmune diseases share similar clinical and pathogenic features. Thus, CNVs of genes involved in immunity may serve as shared determinants of multiple autoimmune diseases. Here, we determined the association between CNV in the gene encoding FCGR3B with the risk of developing autoimmune diseases and whether the observed associations are modified by the CNV in CCL3L1 (CC chemokine ligand 3-like 1), a gene encoding a potent chemokine. In a cross-sectional study of 774 subjects, we estimated FCGR3B and CCL3L1 gene copy number in 146, 158 and 61 subjects with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and primary Sjögren's syndrome (SS), respectively, and 409 healthy controls. The median gene dose of FCGR3B in the study population was two. FCGR3B copy numberor2 was associated with an increased risk of SLE and primary SS but not RA. This association was mostly evident in subjects who also had two copies of CCL3L1. Thus, our data suggest that epistatic interactions between CNV of FCGR3B and CCL3L1, two immune response genes, may influence phenotypically related autoimmune diseases. |
| Databáze: | OpenAIRE |
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