Sedation during Minimal Invasive Surfactant Therapy in Preterm Infants
| Autor: | Esther G.J. Rijntjes-Jacobs, Enrico Lopriore, Janneke Dekker, Arjan B. te Pas, Monique Rijken, Vivianne E.H.J. Smits-Wintjens |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Bradycardia Birth weight Sedation Gestational Age Surfactant therapy Intermittent Positive-Pressure Ventilation law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law 030225 pediatrics otorhinolaryngologic diseases Birth Weight Humans Hypnotics and Sedatives Medicine 030212 general & internal medicine Propofol Netherlands Retrospective Studies Respiratory Distress Syndrome Newborn business.industry Infant Newborn Gestational age Pulmonary Surfactants Retrospective cohort study Comfort Anesthesia Pediatrics Perinatology and Child Health Minimally invasive surfactant therapy Preterm infant Female Hypotension medicine.symptom business Infant Premature Developmental Biology medicine.drug |
| Zdroj: | Neonatology, 109(4), 308-313 |
| Popis: | Background: There is no data available whether sedation should be given during minimally invasive surfactant therapy (MIST). Objective: To compare the level of comfort of preterm infants receiving sedation versus no sedation for MIST. Methods: A retrospective study of preterm infants receiving MIST was performed in Leiden University Medical Center in 2014. Sedation (propofol 1 mg/kg) was optional and left to the discretion of the caregiver. Standardized COMFORTneo scores were compared, and COMFORTneo Results: In 38 infants receiving MIST, 23 received propofol and 15 were not sedated. Mean (SD) gestational age [29 (2) vs. 29 (3) weeks] and birth weight [1,312 (483) vs. 1,469 (588) g] were not different. Median (IQR) COMFORTneo was not different between the groups before [11 (9-15) vs. 10 (8-12)] and after MIST [10 (8-12) vs. 9 (8-10)], but lower in the sedated group during MIST [12 (9-17) vs. 20 (15-23)] with more often COMFORTneo Conclusions: Preterm infants receiving MIST were more comfortable when sedation was given, but needed ventilation more often. A randomized controlled trial is warranted to test whether the benefit of sedation outweighs the risks of complications. |
| Databáze: | OpenAIRE |
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