Hox Repertoires for Motor Neuron Diversity and Connectivity Gated by a Single Accessory Factor, FoxP1
| Autor: | Jeremy S. Dasen, Alessandro De Camilli, Bin Wang, Philip W. Tucker, Thomas M. Jessell |
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| Rok vydání: | 2008 |
| Předmět: |
EVO_ECOL
Cellular differentiation Green Fluorescent Proteins DEVBIO Mice Transgenic Chick Embryo Biology MOLNEURO General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Mice 0302 clinical medicine Motor system medicine Animals Hox gene Transcription factor 030304 developmental biology Regulation of gene expression Homeodomain Proteins Motor Neurons 0303 health sciences Extramural Biochemistry Genetics and Molecular Biology(all) Gene Expression Regulation Developmental Cell Differentiation Forkhead Transcription Factors Anatomy FOXP1 Motor neuron Repressor Proteins medicine.anatomical_structure nervous system Spinal Cord Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Cell. 134(2):304-316 |
| ISSN: | 0092-8674 |
| DOI: | 10.1016/j.cell.2008.06.019 |
| Popis: | SummaryThe precision with which motor neurons innervate target muscles depends on a regulatory network of Hox transcription factors that translates neuronal identity into patterns of connectivity. We show that a single transcription factor, FoxP1, coordinates motor neuron subtype identity and connectivity through its activity as a Hox accessory factor. FoxP1 is expressed in Hox-sensitive motor columns and acts as a dose-dependent determinant of columnar fate. Inactivation of Foxp1 abolishes the output of the motor neuron Hox network, reverting the spinal motor system to an ancestral state. The loss of FoxP1 also changes the pattern of motor neuron connectivity, and in the limb motor axons appear to select their trajectories and muscle targets at random. Our findings show that FoxP1 is a crucial determinant of motor neuron diversification and connectivity, and clarify how this Hox regulatory network controls the formation of a topographic neural map. |
| Databáze: | OpenAIRE |
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